| Gene Information | |
|---|---|
| Gene Name | MARKL1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 752 |
| Protein Names | MAP/microtubule affinity-regulating kinase 4 (EC 2.7.11.1) (MAP/microtubule affinity-regulating kinase-like 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q96L34 |
| Gene Card | MARK4 |
| Uniprot ID | Q96L34 |
| Pfam | PF02149; PF00069; PF00627 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. Isoform 2 is brain-specific (PubMed:11326310). Expressed at highest levels in brain and testis. Also expressed in heart, lung, liver, muscle, kidney and spleen (PubMed:14594945). {ECO:0000269|PubMed:11326310, ECO:0000269|PubMed:14594945}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5ES1 (X-ray 2.80A ) |
| DBSNP | rs35070611 rs780763668 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14594945}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000269|PubMed:14594945}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:23400999}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:23400999}. Cytoplasm {ECO:0000269|PubMed:23400999, ECO:0000269|PubMed:23666762}. Cell projection, dendrite {ECO:0000269|PubMed:23666762}. Note=Localized at the tips of neurite-like processes in differentiated neuroblast cells. Detected in the cytoplasm and neuropil of the hippocampus. {ECO:0000269|PubMed:14594945, ECO:0000269|PubMed:23666762}. |
| Mouse PG classification | NA |
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