| Gene Information | |
|---|---|
| Gene Name | ATP11A |
| Organism | Homo sapiens (Human) |
| Gene Length | 1134 |
| Protein Names | Phospholipid-transporting ATPase IH (EC 7.6.2.1) (ATPase IS) (ATPase class VI type 11A) (P4-ATPase flippase complex alpha subunit ATP11A) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000068650 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P98196 |
| Gene Card | ATP11A |
| Uniprot ID | P98196 |
| Pfam | PF16212; PF16209 |
| In ASD | no |
| Allosteric Prediction | no (-0.106620417) |
| Ortholog in Animals | Alpaca_ ATP11A ( ortholog_one2one ) Dog_ ATP11A ( ortholog_one2one ) GuineaPig_ ATP11A ( ortholog_one2one ) Macaque_ ATP11A ( ortholog_one2one ) Mouse_ Atp11a ( ortholog_one2one ) Pig_ ATP11A ( ortholog_one2one ) Rat_ Atp11a ( ortholog_one2one ) Rabbit_ ATP11A ( ortholog_one2one ) |
| Ohnologs | ATP11C, ATP11B |
| Paralogs | ATP8B4, ATP10D, ATP8A2, ATP11C, ATP10A, ATP11B, ATP8B1, ATP9A, ATP10B, ATP8B2, ATP8A1, ATP9B, ATP8B3 |
| Tissue | NA |
| Tissue Specificity | Widely expressed (PubMed:26567335). Expressed in myoblasts (PubMed:29799007). {ECO:0000269|PubMed:26567335, ECO:0000269|PubMed:29799007}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs368865 rs11616795 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:21914794, ECO:0000269|PubMed:25315773, ECO:0000269|PubMed:25947375, ECO:0000269|PubMed:34403372}; Multi-pass membrane protein {ECO:0000255}. Early endosome {ECO:0000269|PubMed:21914794}. Recycling endosome {ECO:0000269|PubMed:21914794}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:21914794, ECO:0000269|PubMed:25315773, ECO:0000269|PubMed:25947375}; Multi-pass membrane protein {ECO:0000255}. Note=Efficient exit from the endoplasmic reticulum requires the presence of TMEM30A. {ECO:0000269|PubMed:25315773, ECO:0000269|PubMed:25947375}. |
| Mouse PG classification | NA |
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