| Gene Information | |
|---|---|
| Gene Name | HARS2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 506 |
| Protein Names | Histidine--tRNA ligase, mitochondrial (EC 6.1.1.21) (Histidine--tRNA ligase-like) (Histidyl-tRNA synthetase) (HisRS) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000112855 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P49590 |
| Gene Card | HARS2 |
| Uniprot ID | P49590 |
| Pfam | PF03129; PF13393 |
| In ASD | no |
| Allosteric Prediction | no (-0.566428214) |
| Ortholog in Animals | Alpaca_ HARS2 ( ortholog_one2one ) Dog_ HARS2 ( ortholog_one2one ) GuineaPig_ HARS2 ( ortholog_one2one ) Macaque_ HARS2 ( ortholog_one2one ) Mouse_ Hars2 ( ortholog_one2one ) Pig_ HARS2 ( ortholog_one2one ) Rat_ Hars2 ( ortholog_one2one ) Rabbit_ HARS2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | HARS1 |
| Tissue | NA |
| Tissue Specificity | A high level expression is seen in the heart, kidney and skeletal muscle while a lower level expression is seen in the brain and liver. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs397515410 rs376177973 |
| Subcellular location [CC] | Mitochondrion {ECO:0000269|PubMed:21464306}. |
| Mouse PG classification | NA |
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