| Gene Information | |
|---|---|
| Gene Name | KLHDC2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 406 |
| Protein Names | Kelch domain-containing protein 2 (Hepatocellular carcinoma-associated antigen 33) (Host cell factor homolog LCP) (Host cell factor-like protein 1) (HCLP-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000165516 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9Y2U9 |
| Gene Card | KLHDC2 |
| Uniprot ID | Q9Y2U9 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.48195324) |
| Ortholog in Animals | Alpaca_ KLHDC2 ( ortholog_one2one ) Dog_ KLHDC2 ( ortholog_one2one ) GuineaPig_ KLHDC2 ( ortholog_one2one ) Macaque_ KLHDC2 ( ortholog_one2one ) Mouse_ Klhdc2 ( ortholog_one2one ) Pig_ KLHDC2 ( ortholog_one2one ) Rat_ AABR07039218.1 ( ortholog_one2many ) Rat_ Klhdc2 ( ortholog_one2many ) Rabbit_ KLHDC2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | HCFC2, KLHDC4, FBXO42, KLHDC3, KLHDC1, KLHDC9, KLHDC10, RABEPK, LZTR1, HCFC1 |
| Tissue | NA |
| Tissue Specificity | Widely expressed, with high levels in skeletal muscle, heart, pancreas and liver (PubMed:11384994, PubMed:16964437). Undetectable in peripheral blood leukocytes (PubMed:16964437). {ECO:0000269|PubMed:11384994, ECO:0000269|PubMed:16964437}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6DO3 (X-ray 2.17A ) 6DO4 (X-ray 2.20A ) 6DO5 (X-ray 2.50A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:11384994, ECO:0000269|PubMed:16964437}. |
| Mouse PG classification | NA |
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