| Gene Information | |
|---|---|
| Gene Name | BEST4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 473 |
| Protein Names | Bestrophin-4 (Vitelliform macular dystrophy 2-like protein 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000142959 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q8NFU0 |
| Gene Card | BEST4 |
| Uniprot ID | Q8NFU0 |
| Pfam | PF01062 |
| In ASD | no |
| Allosteric Prediction | no (-0.604637766) |
| Ortholog in Animals | Alpaca_ BEST4 ( ortholog_one2one ) Dog_ BEST4 ( ortholog_one2one ) GuineaPig_ BEST4 ( ortholog_one2one ) Macaque_ BEST4 ( ortholog_one2one ) Pig_ BEST4 ( ortholog_one2one ) Rat_ Best4 ( ortholog_one2one ) Rabbit_ BEST4 ( ortholog_one2one ) |
| Ohnologs | BEST2 |
| Paralogs | BEST3, BEST1, BEST2 |
| Tissue | colon, duodenum, rectum, sigmoid.colon, small.intestine, transverse.colon |
| Tissue Specificity | Predominantly found in colon and the weakly in fetal brain, spinal cord, retina, lung, trachea, testis and placenta. {ECO:0000269|PubMed:12032738}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs16832245 rs16832242 rs16832241 rs16832239 |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. |
| Mouse PG classification | NA |
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