| Gene Information | |
|---|---|
| Gene Name | UNQ213/PRO239 |
| Organism | Homo sapiens (Human) |
| Gene Length | 858 |
| Protein Names | Volume-regulated anion channel subunit LRRC8D (Leucine-rich repeat-containing protein 5) (Leucine-rich repeat-containing protein 8D) (HsLRRC8D) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q7L1W4 |
| Gene Card | LRRC8D |
| Uniprot ID | Q7L1W4 |
| Pfam | PF13855; PF12534 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6M04 (EM 4.36A ) |
| DBSNP | rs11552246 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:24782309, ECO:0000269|PubMed:24790029, ECO:0000269|PubMed:28193731}; Multi-pass membrane protein {ECO:0000269|PubMed:32415200}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:24782309, ECO:0000305|PubMed:24790029}; Multi-pass membrane protein {ECO:0000269|PubMed:32415200}. Note=In the absence of LRRC8A, resides primarily in a cytoplasmic compartment, probably the endoplasmic reticulum (PubMed:24782309, PubMed:24790029). Requires LRRC8A for expression at the cell membrane (PubMed:24790029). {ECO:0000269|PubMed:24782309, ECO:0000269|PubMed:24790029}. |
| Mouse PG classification | NA |
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