| Gene Information | |
|---|---|
| Gene Name | KIZ |
| Organism | Homo sapiens (Human) |
| Gene Length | 673 |
| Protein Names | Centrosomal protein kizuna (Polo-like kinase 1 substrate 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000088970 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q2M2Z5 |
| Gene Card | KIZ |
| Uniprot ID | Q2M2Z5 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-1.082450925) |
| Ortholog in Animals | Alpaca_ KIZ ( ortholog_one2one ) Dog_ KIZ ( ortholog_one2one ) GuineaPig_ KIZ ( ortholog_one2one ) Macaque_ KIZ ( ortholog_one2one ) Mouse_ Kiz ( ortholog_one2one ) Pig_ KIZ ( ortholog_one2one ) Rat_ Kiz ( ortholog_one2one ) Rabbit_ KIZ ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);0.175650(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs4815025 rs2236178 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:16980960}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:24680887}. Note=Localizes to centrosomes throughout the cell cycle. After centrosome duplication, it usually remains associated only with the mother centrosome, containing the older mature centriole and particles surrounding it. During prophase, additional particles accumulate around both separating centrosomes. Does not accumulate at the microtubule minus ends, but instead localizes to the centrosomes and centrosome-surrounding area in a microtubule-independent and dependent manner, respectively. {ECO:0000269|PubMed:24680887}. |
| Mouse PG classification | NA |
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