| Gene Information | |
|---|---|
| Gene Name | KITLG |
| Organism | Homo sapiens (Human) |
| Gene Length | 273 |
| Protein Names | Kit ligand (Mast cell growth factor) (MGF) (Stem cell factor) (SCF) (c-Kit ligand) [Cleaved into: Soluble KIT ligand (sKITLG)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000049130 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P21583 |
| Gene Card | KITLG |
| Uniprot ID | P21583 |
| Pfam | PF02404 |
| In ASD | no |
| Allosteric Prediction | yes (0.254450307) |
| Ortholog in Animals | Alpaca_ KITLG ( ortholog_one2one ) Dog_ KITLG ( ortholog_one2one ) GuineaPig_ KITLG ( ortholog_one2one ) Macaque_ KITLG ( ortholog_one2one ) Mouse_ Kitl ( ortholog_one2one ) Pig_ KITLG ( ortholog_one2one ) Rat_ Kitlg ( ortholog_one2one ) Rabbit_ KITLG ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1EXZ (X-ray 2.30A ) 1SCF (X-ray 2.20A ) 2E9W (X-ray 3.50A ) |
| DBSNP | rs121918653 rs3741457 rs864309655 rs41283112 rs12721563 |
| Subcellular location [CC] | [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:26522471}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:26522471}; Single-pass type I membrane protein {ECO:0000250}. Cell projection, lamellipodium {ECO:0000269|PubMed:26522471}. Cell projection, filopodium {ECO:0000269|PubMed:26522471}.; [Soluble KIT ligand]: Secreted. |
| Mouse PG classification | HPG |
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