| Gene Information | |
|---|---|
| Gene Name | KIT |
| Organism | Homo sapiens (Human) |
| Gene Length | 976 |
| Protein Names | Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117) |
| Target Name | mast/stem cell growth factor receptor kit |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000157404 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P10721 |
| Gene Card | KIT |
| Uniprot ID | P10721 |
| Pfam | PF00047; PF07714 |
| In ASD | yes |
| Allosteric Prediction | yes (1.000131129) |
| Ortholog in Animals | Alpaca_ KIT ( ortholog_one2one ) Dog_ KIT ( ortholog_one2one ) GuineaPig_ KIT ( ortholog_one2one ) Macaque_ KIT ( ortholog_one2one ) Mouse_ Kit ( ortholog_one2one ) Pig_ KIT ( ortholog_one2one ) Rat_ Kit ( ortholog_one2one ) Rabbit_ KIT ( ortholog_one2one ) |
| Ohnologs | PDGFRB, FLT3, CSF1R |
| Paralogs | EPHA7, NTRK1, EPHB3, ALK, FGFR3, EPHA2, LMTK2, EPHB1, EPHA3, INSR, PDGFRA, EGFR, CSF1R, ERBB3, NTRK3, DDR1, ERBB4, EPHA8, TEK, MUSK, MERTK, FGFR4, FLT3, EPHB6, FLT1, DDR2, EPHA6, NTRK2, IGF1R, INSRR, EPHB4, PDGFRB, ERBB2, KDR, EPHA5, FGFR2, TYRO3, MST1R, AXL, EPHB2, ROR1, ROR2, ROS1, EPHA10, EPHA4, RET, LTK, FLT4, TIE1, FGFR1, RYK, EPHA1, MET |
| Tissue | NA |
| Tissue Specificity | [Isoform 3]: In testis, detected in spermatogonia in the basal layer and in interstitial Leydig cells but not in Sertoli cells or spermatocytes inside the seminiferous tubules (at protein level) (PubMed:20601678). Expression is maintained in ejaculated spermatozoa (at protein level) (PubMed:20601678). {ECO:0000269|PubMed:20601678}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001578(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1PKG (X-ray 2.90A ) 1T45 (X-ray 1.90A ) 1T46 (X-ray 1.60A ) 2E9W (X-ray 3.50A ) 2EC8 (X-ray 3.00A ) 2IUH (X-ray 2.00A ) 2VIF (X-ray 1.45A ) 3G0E (X-ray 1.60A ) 3G0F (X-ray 2.60A ) 4HVS (X-ray 1.90A ) 4K94 (X-ray 2.40A ) 4K9E (X-ray 2.70A ) 4PGZ (X-ray 2.40A ) 4U0I (X-ray 2.00A ) 6GQJ (X-ray 2.33A ) 6GQK (X-ray 2.31A ) 6GQL (X-ray 2.01A ) 6GQM (X-ray 2.00A ) 6HH1 (X-ray 2.25A ) 6ITT (X-ray 2.10A ) 6ITV (X-ray 1.88A ) 6KLA (X-ray 2.11A ) 6MOB (X-ray 1.80A ) 6XV9 (X-ray 3.38A ) 6XVA (X-ray 2.30A ) 6XVB (X-ray 2.15A ) 7KHG (X-ray 2.15A ) 7KHJ (X-ray 2.80A ) 7KHK (X-ray 2.34A ) |
| DBSNP | rs55792975 rs753212327 rs3822214 rs3822214 rs121913685 rs121913517 rs121913517 rs121913685 rs121913680 rs28933371 rs794726671 rs121913679 rs35200131 rs56094246 rs751005114 rs1722708855 rs121913684 rs145602440 rs121913506 rs1057519709 rs121913507 rs121913506 rs121913682 rs993022333 rs121913514 rs1057519713 rs121913509 rs121913687 |
| Subcellular location [CC] | [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:20601678}. Note=Detected in the cytoplasm of spermatozoa, especially in the equatorial and subacrosomal region of the sperm head. {ECO:0000269|PubMed:20601678}. |
| Mouse PG classification | HPG |
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