| Gene Information | |
|---|---|
| Gene Name | KISS1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 138 |
| Protein Names | Metastasis-suppressor KiSS-1 (Kisspeptin-1) [Cleaved into: Metastin (Kisspeptin-54); Kisspeptin-14; Kisspeptin-13; Kisspeptin-10] |
| Target Name | metastasis-suppressor kiss-1 |
| Target Type | Clinical trial target |
| Gene Age | 950 ( ENSG00000170498 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q15726 |
| Gene Card | KISS1 |
| Uniprot ID | Q15726 |
| Pfam | PF15152 |
| In ASD | no |
| Allosteric Prediction | no (-0.060656694) |
| Ortholog in Animals | Alpaca_ KISS1 ( ortholog_one2one ) GuineaPig_ KISS1 ( ortholog_one2one ) Macaque_ KISS1 ( ortholog_one2one ) Mouse_ Kiss1 ( ortholog_one2many ) Mouse_ Gm28040 ( ortholog_one2many ) Rat_ Kiss1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | placenta |
| Tissue Specificity | Very high expression in placenta, with the next highest level in testis and moderate levels in pancreas, liver, small intestine and brain at much lower levels. Expression levels increased in both early placentas and molar pregnancies and are reduced in choriocarcinoma cells. Expressed at higher levels in first trimester trophoblasts than at term of gestation, but only expressed in the villous trophoblast. {ECO:0000269|PubMed:11385580, ECO:0000269|PubMed:12414911, ECO:0000269|PubMed:15020672}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs12998 rs35431622 rs4889 |
| Subcellular location [CC] | Secreted. |
| Mouse PG classification | NA |
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