| Gene Information | |
|---|---|
| Gene Name | CDHR2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1310 |
| Protein Names | Cadherin-related family member 2 (Protocadherin LKC) (PC-LKC) (Protocadherin-24) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 424 ( ENSG00000074276 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9BYE9 |
| Gene Card | CDHR2 |
| Uniprot ID | Q9BYE9 |
| Pfam | PF00028 |
| In ASD | no |
| Allosteric Prediction | no (-1.427032211) |
| Ortholog in Animals | Alpaca_ CDHR2 ( ortholog_one2one ) Dog_ CDHR2 ( ortholog_one2one ) GuineaPig_ CDHR2 ( ortholog_one2one ) Macaque_ CDHR2 ( ortholog_one2one ) Mouse_ Cdhr2 ( ortholog_one2one ) Pig_ CDHR2 ( ortholog_one2one ) Rat_ Cdhr2 ( ortholog_one2one ) Rabbit_ CDHR2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CDH7, CDH9, CDH20, CDH4, CDH18, PCDH1, PCDH20, CDH26, CDH19, PCDH9, CDH3, PCDH11Y, PCDH11X, CDH17, CDHR5, CDHR3, DCHS2, CDH24, CDH23, PCDH7, CDH15, CDHR1, DCHS1, CDH11, CDH8, CDH10, CDH12, CDH13, CDH6, CDH1, CDH22, CDH5, CDH2 |
| Tissue | duodenum, small.intestine, testis, small.intestine.Peyers.patch |
| Tissue Specificity | Highly expressed in liver, kidney and colon. Moderately expressed in small intestine. Down-regulated in a number of liver and colon cancers (PubMed:12117771, PubMed:15534908). Expressed in duodenum with higher expression in enterocytes along the villus axis and lower expression in crypts (at protein level) (PubMed:24725409). {ECO:0000269|PubMed:12117771, ECO:0000269|PubMed:15534908, ECO:0000269|PubMed:24725409}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 5CZR (X-ray 2.30A ) 7N86 (X-ray 3.17A ) |
| DBSNP | rs6886860 rs3762960 rs11134982 rs752138 rs35018750 rs3749625 rs371676123 rs2291442 rs17078347 |
| Subcellular location [CC] | Apical cell membrane {ECO:0000269|PubMed:12117771, ECO:0000269|PubMed:24725409}; Single-pass type I membrane protein {ECO:0000269|PubMed:12117771, ECO:0000269|PubMed:24725409}. Cell projection, microvillus membrane {ECO:0000269|PubMed:12117771, ECO:0000269|PubMed:24725409}; Single-pass type I membrane protein {ECO:0000269|PubMed:12117771, ECO:0000269|PubMed:24725409}. Cell junction {ECO:0000269|PubMed:12117771}. |
| Mouse PG classification | NA |
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