| Gene Information | |
|---|---|
| Gene Name | INAVA |
| Organism | Homo sapiens (Human) |
| Gene Length | 663 |
| Protein Names | Innate immunity activator protein |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000163362 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q3KP66 |
| Gene Card | INAVA |
| Uniprot ID | Q3KP66 |
| Pfam | PF11819 |
| In ASD | no |
| Allosteric Prediction | no (-1.110413894) |
| Ortholog in Animals | Alpaca_ INAVA ( ortholog_one2one ) Dog_ INAVA ( ortholog_one2one ) GuineaPig_ INAVA ( ortholog_one2one ) Macaque_ INAVA ( ortholog_one2one ) Mouse_ Inava ( ortholog_one2one ) Pig_ INAVA ( ortholog_one2one ) Rat_ Inava ( ortholog_one2one ) Rabbit_ INAVA ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CCDC120 |
| Tissue | small.intestine |
| Tissue Specificity | Highly expressed in intestinal myeloid-derived cells and expressed in monocyte-derived macrophages upon induction by PRR activation. {ECO:0000269|PubMed:28436939, ECO:0000269|PubMed:29420262}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs41313912 rs296520 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:28436939}. Cytoplasm {ECO:0000269|PubMed:28436939}. Note=Translocates to the nucleus upon NOD2 stimulation. {ECO:0000269|PubMed:28436939}. |
| Mouse PG classification | NA |
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