| Gene Information | |
|---|---|
| Gene Name | BIN2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 565 |
| Protein Names | Bridging integrator 2 (Breast cancer-associated protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000110934 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9UBW5 |
| Gene Card | BIN2 |
| Uniprot ID | Q9UBW5 |
| Pfam | PF03114 |
| In ASD | no |
| Allosteric Prediction | no (-0.562248155) |
| Ortholog in Animals | Alpaca_ BIN2 ( ortholog_one2one ) Dog_ BIN2 ( ortholog_one2one ) Macaque_ BIN2 ( ortholog_one2one ) Mouse_ Bin2 ( ortholog_one2one ) Pig_ BIN2 ( ortholog_one2one ) Rat_ Bin2 ( ortholog_one2one ) Rabbit_ BIN2 ( ortholog_one2one ) |
| Ohnologs | BIN1 |
| Paralogs | BIN3, BIN1, AMPH |
| Tissue | whole.blood |
| Tissue Specificity | Detected in natural killer cells (at protein level). Highest level expression seen in spleen and peripheral blood leukocytes and is also expressed at high levels in thymus, colon and placenta, suggesting preferential expression in hematopoietic tissues. {ECO:0000269|PubMed:10903846, ECO:0000269|PubMed:23285027}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 4AVM (X-ray 1.91A ) 4I1Q (X-ray 2.53A ) |
| DBSNP | rs7312857 rs7954976 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:23285027}. Cell projection, podosome membrane {ECO:0000269|PubMed:23285027}; Peripheral membrane protein {ECO:0000269|PubMed:23285027}; Cytoplasmic side {ECO:0000269|PubMed:23285027}. Cytoplasm, cell cortex {ECO:0000269|PubMed:23285027}. Cell projection, phagocytic cup {ECO:0000269|PubMed:23285027}. Note=Associates with membranes enriched in phosphoinositides. Detected in the actin-rich cell cortex at the leading edge of migrating cells. Detected at podosomes, at an actin-rich ring-like structure. {ECO:0000269|PubMed:23285027}. |
| Mouse PG classification | NA |
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