| Gene Information | |
|---|---|
| Gene Name | GHR |
| Organism | Homo sapiens (Human) |
| Gene Length | 638 |
| Protein Names | Growth hormone receptor (GH receptor) (Somatotropin receptor) [Cleaved into: Growth hormone-binding protein (GH-binding protein) (GHBP) (Serum-binding protein)] |
| Target Name | ghr messenger rna |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000112964 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P10912 |
| Gene Card | GHR |
| Uniprot ID | P10912 |
| Pfam | PF09067; PF00041; PF12772 |
| In ASD | yes |
| Allosteric Prediction | yes (1.000257627) |
| Ortholog in Animals | Alpaca_ GHR ( ortholog_one2one ) Dog_ GHR ( ortholog_one2one ) GuineaPig_ GHR ( ortholog_one2one ) Macaque_ GHR ( ortholog_one2one ) Mouse_ Ghr ( ortholog_one2one ) Pig_ GHR ( ortholog_one2one ) Rat_ Ghr ( ortholog_one2one ) Rabbit_ GHR ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CRLF1, IL13RA2, IL11RA, IL13RA1, CNTFR, IL2RG, CRLF2, IL31RA, IL3RA, IL6ST, IL12RB1, CSF3R, IL12RB2, CSF2RA, IL6R, IL27RA, IL23R, LIFR, OSMR, IL5RA, EBI3, PRLR, LEPR |
| Tissue | artery, bone.marrow, breast |
| Tissue Specificity | Expressed in various tissues with high expression in liver and skeletal muscle. Isoform 4 is predominantly expressed in kidney, bladder, adrenal gland and brain stem. Isoform 1 expression in placenta is predominant in chorion and decidua. Isoform 4 is highly expressed in placental villi. Isoform 2 is expressed in lung, stomach and muscle. Low levels in liver. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1A22 (X-ray 2.60A ) 1AXI (X-ray 2.10A ) 1HWG (X-ray 2.50A ) 1HWH (X-ray 2.90A ) 1KF9 (X-ray 2.60A ) 2AEW (X-ray 2.70A ) 3HHR (X-ray 2.80A ) 5OEK (NMR - ) 5OHD (NMR - ) |
| DBSNP | rs121909361 rs121909357 rs121909365 rs6413484 rs6413484 rs121909366 rs121909367 rs121909368 rs121909369 rs121909362 rs6181 rs6177 rs45588036 rs1164396446 rs6182 rs34283856 rs6183 rs6180 rs6184 |
| Subcellular location [CC] | Cell membrane; Single-pass type I membrane protein. Note=On growth hormone binding, GHR is ubiquitinated, internalized, down-regulated and transported into a degradative or non-degradative pathway. {ECO:0000250}.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein. Note=Remains fixed to the cell membrane and is not internalized.; [Growth hormone-binding protein]: Secreted. Note=Complexed to a substantial fraction of circulating GH. {ECO:0000250}. |
| Mouse PG classification | LPG |
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