| Gene Information | |
|---|---|
| Gene Name | KIR2DL1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 348 |
| Protein Names | Killer cell immunoglobulin-like receptor 2DL1 (CD158 antigen-like family member A) (Natural killer-associated transcript 1) (NKAT-1) (p58 natural killer cell receptor clones CL-42/47.11) (p58 NK receptor CL-42/47.11) (p58.1 MHC class-I-specific NK receptor) (CD antigen CD158a) |
| Target Name | mhc class i nk cell receptor 2dl1 |
| Target Type | Clinical trial target |
| Gene Age | 86 ( ENSG00000125498 ) 3 ( ENSG00000273510 ) 3 ( ENSG00000273794 ) 3 ( ENSG00000274692 ) 3 ( ENSG00000274782 ) 3 ( ENSG00000274926 ) 3 ( ENSG00000275080 ) 3 ( ENSG00000275196 ) 3 ( ENSG00000275276 ) 3 ( ENSG00000275522 ) 3 ( ENSG00000275750 ) 3 ( ENSG00000276310 ) 3 ( ENSG00000276625 ) 3 ( ENSG00000276820 ) 3 ( ENSG00000277356 ) 3 ( ENSG00000277616 ) 3 ( ENSG00000277833 ) 3 ( ENSG00000278207 ) 3 ( ENSG00000278248 ) 3 ( ENSG00000278495 ) 3 ( ENSG00000278503 ) 3 ( ENSG00000278738 ) 3 ( ENSG00000278755 ) 3 ( ENSG00000278805 ) 3 ( ENSG00000278821 ) 3 ( ENSG00000283723 ) 3 ( ENSG00000284100 ) 3 ( ENSG00000284145 ) 3 ( ENSG00000284347 ) 3 ( ENSG00000284401 ) 3 ( ENSG00000284514 ) 3 ( ENSG00000284530 ) 3 ( ENSG00000284551 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P43626 |
| Gene Card | KIR2DL1 |
| Uniprot ID | P43626 |
| Pfam | PF00047 |
| In ASD | no |
| Allosteric Prediction | no (-0.72593811) |
| Ortholog in Animals | Mouse_ Kir3dl1 ( ortholog_many2many ) Mouse_ Kir3dl2 ( ortholog_many2many ) Rat_ Kir3dl1 ( ortholog_one2many ) |
| Ohnologs | NA |
| Paralogs | KIR2DL3, KIR2DS4, KIR3DL3, KIR3DL2, KIR3DL1, KIR2DL4, FCAR, LILRB2, LILRB5, LILRA2, LILRA4, LILRA6, LILRA5, NCR1, LILRB4, LILRB1, LILRA1, LILRB3, GP6, IGSF1, OSCAR, TARM1, VSTM1, LAIR2, A1BG |
| Tissue | NA |
| Tissue Specificity | Expressed by NK cells. {ECO:0000269|PubMed:9430221}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1IM9 (X-ray 2.80A ) 1NKR (X-ray 1.70A ) |
| DBSNP | rs2304224 rs3810343 rs35509911 rs673568 rs687885 rs11673144 rs111799279 rs147072532 rs666590 rs75232650 rs34721508 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:18624290}; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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