| Gene Information | |
|---|---|
| Gene Name | KIND2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 680 |
| Protein Names | Fermitin family homolog 2 (Kindlin-2) (Mitogen-inducible gene 2 protein) (MIG-2) (Pleckstrin homology domain-containing family C member 1) (PH domain-containing family C member 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q96AC1 |
| Gene Card | FERMT2 |
| Uniprot ID | Q96AC1 |
| Pfam | PF00373; PF18124; PF00169 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. Found in numerous tumor tissues. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2LGX (NMR - ) 2LKO (NMR - ) 2MSU (NMR - ) 4F7H (X-ray 1.90A ) 6U4N (NMR - ) 6XTJ (X-ray 1.60A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, stress fiber. Cell junction, focal adhesion. Membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Cytoplasm, myofibril, sarcomere, I band {ECO:0000250}. Cell surface {ECO:0000250}. Note=Colocalizes with actin stress fibers at cell-ECM focal adhesion sites. Colocalizes with ITGB3 at lamellipodia at the leading edge of spreading cells. Binds to membranes that contain phosphatidylinositides. |
| Mouse PG classification | NA |
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