| Gene Information | |
|---|---|
| Gene Name | HNF4A |
| Organism | Homo sapiens (Human) |
| Gene Length | 474 |
| Protein Names | Hepatocyte nuclear factor 4-alpha (HNF-4-alpha) (Nuclear receptor subfamily 2 group A member 1) (Transcription factor 14) (TCF-14) (Transcription factor HNF-4) |
| Target Name | hepatocyte nuclear factor 4-alpha |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000101076 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P41235 |
| Gene Card | HNF4A |
| Uniprot ID | P41235 |
| Pfam | PF00104; PF00105 |
| In ASD | no |
| Allosteric Prediction | yes (1.212563652) |
| Ortholog in Animals | Alpaca_ HNF4A ( ortholog_one2one ) Dog_ HNF4A ( ortholog_one2one ) GuineaPig_ HNF4A ( ortholog_one2one ) Macaque_ HNF4A ( ortholog_one2one ) Mouse_ Hnf4a ( ortholog_one2one ) Pig_ HNF4A ( ortholog_one2one ) Rat_ Hnf4a ( ortholog_one2one ) Rabbit_ HNF4A ( ortholog_one2one ) |
| Ohnologs | HNF4G, RXRB |
| Paralogs | RXRB, NR2E3, NR2F2, RXRA, NR2F6, HNF4G, RXRG, NR2C2, NR2C1, NR2F1, NR2E1 |
| Tissue | liver, small.intestine.Peyers.patch, transverse.colon |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.04(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1PZL (X-ray 2.10A ) 3CBB (X-ray 2.00A ) 3FS1 (X-ray 2.20A ) 4B7W (X-ray 4.00A ) 4IQR (X-ray 2.90A ) 6CHT (X-ray 3.17A ) |
| DBSNP | rs587777732 rs137853336 rs1800961 rs139779712 rs137853338 rs137853337 rs1063239 rs776824742 |
| Subcellular location [CC] | Nucleus. |
| Mouse PG classification | LPG |
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