| Gene Information | |
|---|---|
| Gene Name | KIF5A |
| Organism | Homo sapiens (Human) |
| Gene Length | 1032 |
| Protein Names | Kinesin heavy chain isoform 5A (Kinesin heavy chain neuron-specific 1) (Neuronal kinesin heavy chain) (NKHC) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000155980 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q12840 |
| Gene Card | KIF5A |
| Uniprot ID | Q12840 |
| Pfam | PF00225 |
| In ASD | no |
| Allosteric Prediction | yes (0.533094854) |
| Ortholog in Animals | Alpaca_ KIF5A ( ortholog_one2one ) Dog_ KIF5A ( ortholog_one2one ) GuineaPig_ KIF5A ( ortholog_one2one ) Macaque_ KIF5A ( ortholog_one2one ) Mouse_ Kif5a ( ortholog_one2one ) Pig_ KIF5A ( ortholog_one2one ) Rat_ Kif5a ( ortholog_one2one ) Rabbit_ KIF5A ( ortholog_one2one ) |
| Ohnologs | KIF5C, KIF5B |
| Paralogs | KIF27, KIF1C, KIF26B, KIF2B, KIF13A, KIFC3, KIFC2, KIF16B, KIF4A, KIF2A, KIF20A, KIF22, KIF3A, KIF13B, KIF5B, KIF1A, KIF3B, KIF3C, KIF1B, CENPE, KIF26A, KIF23, KIF7, KIF18B, KIF25, KIF9, KIF6, KIF14, KIF21B, KIF11, KIF15, KIFC1, KIF12, KIF4B, KIF24, KIF2C, KIF21A, KIF19, KIF17, KIF5C, KIF18A |
| Tissue | brain, cerebral.cortex |
| Tissue Specificity | Distributed throughout the CNS but is highly enriched in subsets of neurons. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.127407(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4UXT (EM 7.40A ) 4UXY (EM 6.50A ) 4UY0 (EM 7.70A ) |
| DBSNP | rs387907287 rs387907285 rs121434441 rs121434443 rs121434442 rs387907288 rs121434444 rs1399145820 rs1373971092 rs754373609 rs113247976 rs1555179087 |
| Subcellular location [CC] | Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q6QLM7}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q6QLM7}. Perikaryon {ECO:0000250|UniProtKB:Q6QLM7}. Note=Concentrated in the cell body of the neurons, particularly in the perinuclear region. {ECO:0000250|UniProtKB:Q6QLM7}. |
| Mouse PG classification | NA |
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