| Gene Information | |
|---|---|
| Gene Name | ATP12A |
| Organism | Homo sapiens (Human) |
| Gene Length | 1039 |
| Protein Names | Potassium-transporting ATPase alpha chain 2 (HK alpha 2) (Non-gastric H(+)/K(+) ATPase subunit alpha) (EC 7.2.2.19) (Non-gastric Na(+)/K(+) ATPase subunit alpha) (EC 7.2.2.13) (Proton pump) (Sodium pump) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000075673 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P54707 |
| Gene Card | ATP12A |
| Uniprot ID | P54707 |
| Pfam | PF00689; PF00690 |
| In ASD | no |
| Allosteric Prediction | yes (0.456802014) |
| Ortholog in Animals | Alpaca_ ATP12A ( ortholog_one2one ) GuineaPig_ ATP12A ( ortholog_one2one ) Macaque_ ATP12A ( ortholog_one2one ) Mouse_ Atp12a ( ortholog_one2one ) Pig_ ATP12A ( ortholog_one2one ) Rat_ Atp12a ( ortholog_one2one ) Rabbit_ ATP12A ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ATP2B4, ATP13A3, ATP7A, ATP2A3, ATP2B3, ATP1A3, ATP13A2, ATP2B2, ATP13A4, ATP7B, ATP13A5, ATP2B1, ATP1A4, ATP2C2, ATP1A1, ATP1A2, ATP2A1, ATP2A2, ATP4A, ATP2C1, ATP13A1 |
| Tissue | esophagus, kidney, tonsil |
| Tissue Specificity | Expressed in airway epithelial cells (at protein level) (PubMed:29391451). Found in skin and kidney. Detected in prostate basal cells (at protein level). Expression is increased in benign prostate hyperplasia and tumor tissues (at protein level). {ECO:0000269|PubMed:22179016, ECO:0000269|PubMed:29391451, ECO:0000269|PubMed:9872395}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs2289909 |
| Subcellular location [CC] | Apical cell membrane {ECO:0000269|PubMed:16914892}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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