| Gene Information | |
|---|---|
| Gene Name | KIF2C |
| Organism | Homo sapiens (Human) |
| Gene Length | 725 |
| Protein Names | Kinesin-like protein KIF2C (Kinesin-like protein 6) (Mitotic centromere-associated kinesin) (MCAK) |
| Target Name | kinesin-like protein kif2c |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000142945 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q99661 |
| Gene Card | KIF2C |
| Uniprot ID | Q99661 |
| Pfam | PF00225 |
| In ASD | yes |
| Allosteric Prediction | yes (0.891068508) |
| Ortholog in Animals | Alpaca_ KIF2C ( ortholog_one2one ) Dog_ KIF2C ( ortholog_one2one ) GuineaPig_ KIF2C ( ortholog_one2one ) Macaque_ KIF2C ( ortholog_one2one ) Mouse_ Kif2c ( ortholog_one2one ) Pig_ KIF2C ( ortholog_one2one ) Rat_ Kif2c ( ortholog_one2one ) Rabbit_ KIF2C ( ortholog_one2one ) |
| Ohnologs | KIF2A |
| Paralogs | KIF24, KIF27, KIF1C, KIF26B, KIF2B, KIF13A, KIFC3, KIFC2, KIF16B, KIF4A, KIF2A, KIF20A, KIF22, KIF3A, KIF13B, KIF5B, KIF1A, KIF3B, KIF3C, KIF1B, CENPE, KIF26A, KIF23, KIF7, KIF5A, KIF18B, KIF25, KIF9, KIF6, KIF14, KIF21B, KIF11, KIF15, KIFC1, KIF12, KIF4B, KIF21A, KIF19, KIF17, KIF5C, KIF18A |
| Tissue | testis |
| Tissue Specificity | Expressed at high levels in thymus and testis, at low levels in small intestine, the mucosal lining of colon, and placenta, and at very low levels in spleen and ovary; expression is not detected in prostate, peripheral blood Leukocytes, heart, brain, lung, liver, skeletal muscle, kidney or pancreas. Isoform 2 is testis-specific. {ECO:0000269|PubMed:12383881, ECO:0000269|PubMed:9434124}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.057143(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2HEH (X-ray 2.15A ) 4UBF (X-ray 3.00A ) 4Y05 (X-ray 2.59A ) 5MIO (X-ray 3.19A ) |
| DBSNP | rs4342887 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19632184, ECO:0000269|PubMed:21820309, ECO:0000269|PubMed:23891108}. Nucleus {ECO:0000250|UniProtKB:P70096}. Chromosome, centromere {ECO:0000269|PubMed:14960279, ECO:0000269|PubMed:17485487}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:14960279, ECO:0000269|PubMed:17485487, ECO:0000269|PubMed:23891108}. Note=Associates with the microtubule network at the growing distal tip (the plus-end) of microtubules, probably through interaction with MTUS2/TIP150 and MAPRE1 (By similarity). Association with microtubule plus ends is also mediated by interaction with KIF18B. Centromeric localization requires the presence of BUB1 and SGO2. {ECO:0000250|UniProtKB:P70096, ECO:0000269|PubMed:17485487, ECO:0000269|PubMed:21820309}. |
| Mouse PG classification | NA |
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