| Gene Information | |
|---|---|
| Gene Name | KIF2A |
| Organism | Homo sapiens (Human) |
| Gene Length | 706 |
| Protein Names | Kinesin-like protein KIF2A (Kinesin-2) (hK2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000068796 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O00139 |
| Gene Card | KIF2A |
| Uniprot ID | O00139 |
| Pfam | PF00225 |
| In ASD | no |
| Allosteric Prediction | no (-0.297930493) |
| Ortholog in Animals | Alpaca_ KIF2A ( ortholog_one2one ) Dog_ KIF2A ( ortholog_one2one ) GuineaPig_ KIF2A ( ortholog_one2one ) Macaque_ KIF2A ( ortholog_one2one ) Mouse_ Kif2a ( ortholog_one2one ) Pig_ KIF2A ( ortholog_one2one ) Rat_ Kif2a ( ortholog_one2many ) Rabbit_ KIF2A ( ortholog_one2one ) |
| Ohnologs | KIF2C |
| Paralogs | KIF27, KIF1C, KIF26B, KIF2B, KIF13A, KIFC3, KIFC2, KIF16B, KIF4A, KIF20A, KIF22, KIF3A, KIF13B, KIF5B, KIF1A, KIF3B, KIF3C, KIF1B, CENPE, KIF26A, KIF23, KIF7, KIF5A, KIF18B, KIF25, KIF9, KIF6, KIF14, KIF21B, KIF11, KIF15, KIFC1, KIF12, KIF4B, KIF24, KIF2C, KIF21A, KIF19, KIF17, KIF5C, KIF18A |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.033333(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2GRY (X-ray 2.35A ) 6BBN (X-ray 3.51A ) |
| DBSNP | rs587777034 rs587777033 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, spindle. Note=Localized to the spindle microtubules and spindle poles from prophase to metaphase. Efficient targeting to spindle microtubules and spindle poles requires the kinase activity of PLK1. Recruited to mitotic spindles by interaction with PSRC1. |
| Mouse PG classification | NA |
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