Gene Information
Gene NameKIF1A
OrganismHomo sapiens (Human)
Gene Length1690
Protein NamesKinesin-like protein KIF1A (Axonal transporter of synaptic vesicles) (Microtubule-based motor KIF1A) (Unc-104- and KIF1A-related protein) (hUnc-104)
Target Namekinesin-like protein kif1a
Target TypeNA
Gene Age645 ( ENSG00000130294 )
Evolutionary StageEukaryota
AlphaFoldDBQ12756
Gene CardKIF1A
Uniprot IDQ12756
PfamPF12473; PF00498; PF12423; PF00225; PF16183; PF00169
In ASDno
Allosteric Predictionyes (0.199814589)
Ortholog in AnimalsAlpaca_ KIF1A ( ortholog_one2one )
Dog_ KIF1A ( ortholog_one2one )
GuineaPig_ KIF1A ( ortholog_one2one )
Macaque_ KIF1A ( ortholog_one2one )
Mouse_ Kif1a ( ortholog_one2one )
Pig_ KIF1A ( ortholog_one2one )
Rat_ Kif1a ( ortholog_one2one )
OhnologsKIF1C, KIF1B
ParalogsKIF27, KIF1C, KIF26B, KIF2B, KIF13A, KIFC3, KIFC2, KIF16B, KIF4A, KIF2A, KIF20A, KIF22, KIF3A, KIF13B, KIF5B, KIF3B, KIF3C, KIF1B, CENPE, KIF26A, KIF23, KIF7, KIF5A, KIF18B, KIF25, KIF9, KIF6, KIF14, KIF21B, KIF11, KIF15, KIFC1, KIF12, KIF4B, KIF24, KIF2C, KIF21A, KIF19, KIF17, KIF5C, KIF18A
Tissuebrain, cerebral.cortex
Tissue SpecificityExpressed in neurons. {ECO:0000269|PubMed:21376300}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 4EGX  (X-ray  2.51A  )  4EJQ  (X-ray  1.89A  )  4UXO  (EM  6.30A  )  4UXP  (EM  6.30A  )  4UXR  (EM  7.00A  )  4UXS  (EM  7.00A  ) 
DBSNP rs797045050  rs182395595  rs672601362  rs786200949  rs869312711  rs387906799  rs672601363  rs1064795534  rs1200817308  rs374178011  rs672601364  rs672601365  rs876661180  rs879253948  rs370623844  rs672601366  rs371039513  rs750125764  rs672601367  rs797045164  rs672601368  rs672601368  rs201314877  rs776660768  rs373882732  rs672601371  rs672601369  rs387906798  rs876661283  rs797045655  rs749718096  rs672601370  rs375423065  rs387907259  rs373042822 
Subcellular location [CC]Cytoplasm, cytoskeleton {ECO:0000269|PubMed:21376300}. Cell projection, neuron projection {ECO:0000269|PubMed:25265257, ECO:0000269|PubMed:32652677, ECO:0000269|PubMed:33880452}. Cell projection, axon {ECO:0000250|UniProtKB:P33173}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P33173}. Synapse {ECO:0000250|UniProtKB:P33173}. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle membrane {ECO:0000250|UniProtKB:F1M4A4};
Peripheral membrane protein {ECO:0000250|UniProtKB:F1M4A4};
Cytoplasmic side {ECO:0000250|UniProtKB:F1M4A4}. Note=Within neuronal cells concentrated in the axon, with smaller amounts in the perinuclear and synaptic regions (By similarity). Accumulates at the distal tip of growing neurites. {ECO:0000250|UniProtKB:P33173, ECO:0000269|PubMed:25265257, ECO:0000269|PubMed:33880452}.
Mouse PG classificationNA
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