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Gene Information
Gene Name
HME
Organism
Homo sapiens (Human)
Gene Length
470
Protein Names
Macrophage metalloelastase (MME) (EC 3.4.24.65) (Macrophage elastase) (ME) (hME) (Matrix metalloproteinase-12) (MMP-12)
Target Name
NA
Target Type
NA
Gene Age
NA
Evolutionary Stage
NA
AlphaFoldDB
P39900
Gene Card
MMP12
Uniprot ID
P39900
Pfam
PF00045; PF00413; PF01471
In ASD
no
Allosteric Prediction
NA
Ortholog in Animals
NA
Ohnologs
NA
Paralogs
NA
Tissue
NA
Tissue Specificity
Found in alveolar macrophages but not in peripheral blood monocytes.
Pharmacological Animal Models
NA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB
1JIZ
(X-ray
2.60A
)
1JK3
(X-ray
1.09A
)
1OS2
(X-ray
2.15A
)
1OS9
(X-ray
1.85A
)
1RMZ
(X-ray
1.34A
)
1ROS
(X-ray
2.00A
)
1UTT
(X-ray
2.20A
)
1UTZ
(X-ray
2.50A
)
1Y93
(X-ray
1.03A
)
1YCM
(NMR
-
)
1Z3J
(NMR
-
)
2HU6
(X-ray
1.32A
)
2JXY
(NMR
-
)
2K2G
(NMR
-
)
2K9C
(NMR
-
)
2KRJ
(NMR
-
)
2MLR
(NMR
-
)
2MLS
(NMR
-
)
2N8R
(NMR
-
)
2OXU
(X-ray
1.24A
)
2OXW
(X-ray
1.15A
)
2OXZ
(X-ray
1.90A
)
2POJ
(NMR
-
)
2W0D
(X-ray
2.00A
)
2WO8
(X-ray
2.00A
)
2WO9
(X-ray
1.70A
)
2WOA
(X-ray
2.30A
)
2Z2D
(NMR
-
)
3BA0
(X-ray
3.00A
)
3EHX
(X-ray
1.90A
)
3EHY
(X-ray
1.90A
)
3F15
(X-ray
1.70A
)
3F16
(X-ray
1.16A
)
3F17
(X-ray
1.10A
)
3F18
(X-ray
1.13A
)
3F19
(X-ray
1.13A
)
3F1A
(X-ray
1.25A
)
3LIK
(X-ray
1.80A
)
3LIL
(X-ray
1.80A
)
3LIR
(X-ray
1.90A
)
3LJG
(X-ray
1.31A
)
3LK8
(X-ray
1.80A
)
3LKA
(X-ray
1.80A
)
3N2U
(X-ray
1.81A
)
3N2V
(X-ray
1.55A
)
3NX7
(X-ray
1.80A
)
3RTS
(X-ray
1.81A
)
3RTT
(X-ray
1.82A
)
3TS4
(X-ray
1.59A
)
3TSK
(X-ray
2.00A
)
3UVC
(X-ray
1.30A
)
4EFS
(X-ray
1.63A
)
4GQL
(X-ray
1.15A
)
4GR0
(X-ray
1.50A
)
4GR3
(X-ray
1.49A
)
4GR8
(X-ray
1.30A
)
4GUY
(X-ray
2.00A
)
4H30
(X-ray
1.43A
)
4H49
(X-ray
2.16A
)
4H76
(X-ray
1.50A
)
4H84
(X-ray
1.59A
)
4I03
(X-ray
1.70A
)
4IJO
(X-ray
1.90A
)
5CXA
(X-ray
1.30A
)
5CZM
(X-ray
1.30A
)
5D2B
(X-ray
1.20A
)
5D3C
(X-ray
1.31A
)
5I0L
(X-ray
2.45A
)
5I2Z
(X-ray
2.30A
)
5I3M
(X-ray
2.17A
)
5I43
(X-ray
1.95A
)
5I4O
(X-ray
2.05A
)
5L79
(X-ray
2.07A
)
5L7F
(X-ray
1.80A
)
5LAB
(X-ray
1.34A
)
5N5J
(X-ray
1.80A
)
5N5K
(X-ray
1.80A
)
6EKN
(X-ray
1.20A
)
6ELA
(X-ray
1.49A
)
6ENM
(X-ray
1.59A
)
6EOX
(X-ray
1.30A
)
6RD0
(X-ray
1.90A
)
6RLY
(X-ray
2.20A
)
7OVY
(X-ray
1.24A
)
DBSNP
rs652438
rs28381701
Subcellular location [CC]
Secreted, extracellular space, extracellular matrix {ECO:0000305}.
Mouse PG classification
NA
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