| Gene Information | |
|---|---|
| Gene Name | KIF14 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1648 |
| Protein Names | Kinesin-like protein KIF14 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000118193 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q15058 |
| Gene Card | KIF14 |
| Uniprot ID | Q15058 |
| Pfam | PF00498; PF00225; PF16183 |
| In ASD | no |
| Allosteric Prediction | no (-0.840223265) |
| Ortholog in Animals | Alpaca_ KIF14 ( ortholog_one2one ) Dog_ KIF14 ( ortholog_one2one ) Macaque_ KIF14 ( ortholog_one2one ) Mouse_ Kif14 ( ortholog_one2one ) Pig_ KIF14 ( ortholog_one2one ) Rat_ Kif14 ( ortholog_one2one ) Rabbit_ KIF14 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | KIF27, KIF1C, KIF26B, KIF2B, KIF13A, KIFC3, KIFC2, KIF16B, KIF4A, KIF2A, KIF20A, KIF22, KIF3A, KIF13B, KIF5B, KIF1A, KIF3B, KIF3C, KIF1B, CENPE, KIF26A, KIF23, KIF7, KIF5A, KIF18B, KIF25, KIF9, KIF6, KIF21B, KIF11, KIF15, KIFC1, KIF12, KIF4B, KIF24, KIF2C, KIF21A, KIF19, KIF17, KIF5C, KIF18A |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs139385693 rs1553259528 rs12120084 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:16431929}. Cytoplasm {ECO:0000269|PubMed:16648480}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:16431929}. Midbody {ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:20309963, ECO:0000269|PubMed:28892560}. Note=Nuclear localization observed during interphase (PubMed:16431929). Nuclear localization triggered by entry into mitosis (PubMed:16648480). Cytoplasmic in interphase (PubMed:16648480). Cytoplasmic in metaphase cells (PubMed:16431929). From prophase to metaphase, accumulates at the developing spindle poles and their associated microtubules. During anaphase, accumulates at the spindle midzone. Localization to the central spindle and midbody during anaphase is dependent upon PRC1 and CIT presence. In cells ready to undergo abscission, concentrates at the contractile ring. {ECO:0000269|PubMed:16431929, ECO:0000269|PubMed:16648480}. |
| Mouse PG classification | NA |
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