| Gene Information | |
|---|---|
| Gene Name | ICA1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 483 |
| Protein Names | Islet cell autoantigen 1 (69 kDa islet cell autoantigen) (ICA69) (Islet cell autoantigen p69) (ICAp69) (p69) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000003147 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q05084 |
| Gene Card | ICA1 |
| Uniprot ID | Q05084 |
| Pfam | PF06456; PF04629 |
| In ASD | no |
| Allosteric Prediction | no (-0.743235981) |
| Ortholog in Animals | Alpaca_ ICA1 ( ortholog_one2one ) Dog_ ICA1 ( ortholog_one2one ) GuineaPig_ ICA1 ( ortholog_one2one ) Macaque_ ICA1 ( ortholog_one2one ) Mouse_ Ica1 ( ortholog_one2one ) Pig_ ICA1 ( ortholog_one2one ) Rat_ Ica1 ( ortholog_one2one ) Rabbit_ ICA1 ( ortholog_one2one ) |
| Ohnologs | ICA1L |
| Paralogs | ICA1L |
| Tissue | NA |
| Tissue Specificity | Expressed abundantly in pancreas, heart and brain with low levels of expression in lung, kidney, liver and thyroid. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:12682071}. Golgi apparatus membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Predominantly cytosolic. Also exists as a membrane-bound form which has been found associated with synaptic vesicles and also with the Golgi complex and immature secretory granules. |
| Mouse PG classification | NA |
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