| Gene Information | |
|---|---|
| Gene Name | KIAA2025 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1133 |
| Protein Names | Roquin-1 (Roquin) (EC 2.3.2.27) (RING finger and C3H zinc finger protein 1) (RING finger and CCCH-type zinc finger domain-containing protein 1) (RING finger protein 198) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q5TC82 |
| Gene Card | RC3H1 |
| Uniprot ID | Q5TC82 |
| Pfam | PF18386; PF13445 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Expressed at higher level in cerebellum, spleen, ovary and liver. {ECO:0000269|Ref.3}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.003361(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3X1O (X-ray 2.20A ) 4QIK (X-ray 1.90A ) 4QIL (X-ray 2.90A ) 4ULW (X-ray 1.91A ) 4YWQ (X-ray 1.70A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, P-body {ECO:0000269|PubMed:31636267}. Cytoplasmic granule {ECO:0000250|UniProtKB:Q4VGL6}. Note=During stress, such as that induced by arsenite treatment, localizes to cytosolic stress granules (By similarity). Localization to stress granules, but not to P-bodies, depends upon the RING-type zinc finger (By similarity). ICOS repression may correlate with the localization to P-bodies, not to stress granules (By similarity). {ECO:0000250|UniProtKB:Q4VGL6}. |
| Mouse PG classification | NA |
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