| Gene Information | |
|---|---|
| Gene Name | KIAA0733 |
| Organism | Homo sapiens (Human) |
| Gene Length | 693 |
| Protein Names | TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 2) (TAK1-binding protein 2) (TAB-2) (TGF-beta-activated kinase 1-binding protein 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9NYJ8 |
| Gene Card | TAB2 |
| Uniprot ID | Q9NYJ8 |
| Pfam | PF02845 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed. In the embryo, expressed in the ventricular trabeculae, endothelial cells of the conotruncal cushions of the outflow tract and in the endothelial cells lining the developing aortic valves. {ECO:0000269|PubMed:10882101, ECO:0000269|PubMed:20493459}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002061(Rat);0.05(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 2DAE (NMR - ) 2WWZ (X-ray 1.40A ) 2WX0 (X-ray 2.40A ) 2WX1 (X-ray 3.00A ) |
| DBSNP | rs267607101 rs267607100 rs886039238 |
| Subcellular location [CC] | Membrane {ECO:0000269|PubMed:10882101, ECO:0000269|PubMed:24434549}; Peripheral membrane protein {ECO:0000269|PubMed:10882101}. Endosome membrane {ECO:0000269|PubMed:24434549}; Peripheral membrane protein {ECO:0000269|PubMed:10882101}. Lysosome membrane {ECO:0000269|PubMed:24434549}; Peripheral membrane protein {ECO:0000269|PubMed:10882101}. Cytoplasm, cytosol {ECO:0000269|PubMed:10882101, ECO:0000269|PubMed:24434549}. Note=Following IL1 stimulation, translocation occurs from the membrane to cytosol (PubMed:10882101). Interaction with TRIM38 promotes translocation from cytosol to endosome and lysosome (PubMed:24434549). {ECO:0000269|PubMed:10882101, ECO:0000269|PubMed:24434549}. |
| Mouse PG classification | NA |
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