| Gene Information | |
|---|---|
| Gene Name | TUBB2A |
| Organism | Homo sapiens (Human) |
| Gene Length | 445 |
| Protein Names | Tubulin beta-2A chain (Tubulin beta class IIa) |
| Target Name | tubulin beta-2 chain |
| Target Type | Successful target |
| Gene Age | 382 ( ENSG00000137267 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q13885 |
| Gene Card | TUBB2A |
| Uniprot ID | Q13885 |
| Pfam | PF00091; PF03953 |
| In ASD | no |
| Allosteric Prediction | yes (0.58755098) |
| Ortholog in Animals | Mouse_ Tubb2a ( ortholog_one2one ) Pig_ TUBB2A ( ortholog_one2one ) Rat_ Tubb2a ( ortholog_one2one ) Rabbit_ TUBB2A ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TUBB2B, TUBB, TUBA4B, TUBA8, TUBA4A, TUBB6, TUBB3, TUBAL3, TUBG2, TUBB8, TUBB8B, TUBE1, TUBB1, TUBB4B, TUBB4A, TUBA1B, TUBA1A, TUBA1C, TUBA3E, TUBA3C, TUBA3D, TUBD1, TUBG1 |
| Tissue | NA |
| Tissue Specificity | High expression in brain, where it represents 30% of all beta-tubulins. {ECO:0000269|PubMed:20191564}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 7NVN (EM 3.00A ) |
| DBSNP | rs774124807 rs886037663 rs2808001 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000250}. |
| Mouse PG classification | NA |
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