| Gene Information | |
|---|---|
| Gene Name | PPP2R1A |
| Organism | Homo sapiens (Human) |
| Gene Length | 589 |
| Protein Names | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (Medium tumor antigen-associated 61 kDa protein) (PP2A subunit A isoform PR65-alpha) (PP2A subunit A isoform R1-alpha) |
| Target Name | serine/threonine-protein phosphatase 2a 65 kda regulatory subunit a alpha isoform |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000105568 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P30153 |
| Gene Card | PPP2R1A |
| Uniprot ID | P30153 |
| Pfam | PF02985 |
| In ASD | no |
| Allosteric Prediction | yes (0.898288396) |
| Ortholog in Animals | Alpaca_ PPP2R1A ( ortholog_one2one ) Dog_ PPP2R1A ( ortholog_one2one ) Macaque_ PPP2R1A ( ortholog_one2one ) Mouse_ Ppp2r1a ( ortholog_one2one ) Pig_ PPP2R1A ( ortholog_one2one ) Rat_ Ppp2r1a ( ortholog_one2one ) Rabbit_ PPP2R1A ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PPP4R1, PPP2R1B |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.400739(Rat);0.158904(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1B3U (X-ray 2.30A ) 2IE3 (X-ray 2.80A ) 2IE4 (X-ray 2.60A ) 2NPP (X-ray 3.30A ) 2NYL (X-ray 3.80A ) 2NYM (X-ray 3.60A ) 2PKG (X-ray 3.30A ) 3C5W (X-ray 2.80A ) 3DW8 (X-ray 2.85A ) 3K7V (X-ray 2.85A ) 3K7W (X-ray 2.96A ) 4I5L (X-ray 2.43A ) 4I5N (X-ray 2.80A ) 4LAC (X-ray 2.82A ) 5W0W (X-ray 3.80A ) 6IUR (X-ray 3.33A ) 6NTS (EM 3.63A ) 7CUN (EM 3.50A ) 7K36 (EM 3.30A ) 7PKS (EM 3.60A ) 7SOY (EM 3.40A ) |
| DBSNP | rs786205228 rs786205227 rs863225094 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:Q32PI5}. Nucleus {ECO:0000269|PubMed:30611118}. Chromosome, centromere {ECO:0000269|PubMed:16580887}. Lateral cell membrane {ECO:0000269|PubMed:15525651}. Cell projection, dendrite {ECO:0000269|PubMed:15525651}. Note=Centromeric localization requires the presence of BUB1. {ECO:0000269|PubMed:16580887}. |
| Mouse PG classification | LPG |
| click here to return to the previous page | |