| Gene Information | |
|---|---|
| Gene Name | IL4I1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 567 |
| Protein Names | L-amino-acid oxidase (LAAO) (LAO) (EC 1.4.3.2) (EC 1.4.3.25) (Interleukin-4-induced protein 1) (IL4-induced protein 1) (hIL4I1) (Protein Fig-1) (hFIG1) |
| Target Name | l-amino-acid oxidase |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000104951 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q96RQ9 |
| Gene Card | IL4I1 |
| Uniprot ID | Q96RQ9 |
| Pfam | PF01593 |
| In ASD | no |
| Allosteric Prediction | yes (0.342864653) |
| Ortholog in Animals | Alpaca_ IL4I1 ( ortholog_one2one ) Dog_ IL4I1 ( ortholog_one2one ) GuineaPig_ IL4I1 ( ortholog_one2one ) Macaque_ IL4I1 ( ortholog_one2one ) Mouse_ Il4i1 ( ortholog_one2one ) Pig_ IL4I1 ( ortholog_one2one ) Rat_ Il4i1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | KDM1A, MAOA, SMOX, PPOX, KDM1B, PAOX, MAOB |
| Tissue | appendix, testis |
| Tissue Specificity | Primarily found in immune tissues, with the highest expression in lymph nodes and spleen (PubMed:12031486, PubMed:12446450). Present in germinal center macrophages and inflammatory myeloid cells and antigen-presenting cells (at protein level) (PubMed:17356132). Also present in spermatozoa (at protein level) (PubMed:25767141). Highly expressed in primary mediastinal large B-cell lymphoma, a specific subtype of diffuse large B-cell lymphoma (PubMed:12446450). Expressed by neoplastic cells of several B-cell lymphomas and by tumor-associated macrophages (PubMed:19436310). {ECO:0000269|PubMed:12031486, ECO:0000269|PubMed:12446450, ECO:0000269|PubMed:17356132, ECO:0000269|PubMed:19436310, ECO:0000269|PubMed:25767141}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs111772144 rs2290772 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:17356132, ECO:0000269|PubMed:28891065, ECO:0000269|PubMed:32818467}. Lysosome {ECO:0000250|UniProtKB:O09046}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:25767141}. Note=Secreted at the immunological synapse. {ECO:0000269|PubMed:28891065}. |
| Mouse PG classification | NA |
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