| Gene Information | |
|---|---|
| Gene Name | SLC11A2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 568 |
| Protein Names | Natural resistance-associated macrophage protein 2 (NRAMP 2) (Divalent cation transporter 1) (Divalent metal transporter 1) (DMT-1) (Solute carrier family 11 member 2) |
| Target Name | natural resistance-associated macrophage protein 2 |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000110911 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P49281 |
| Gene Card | SLC11A2 |
| Uniprot ID | P49281 |
| Pfam | PF01566 |
| In ASD | yes |
| Allosteric Prediction | yes (0.714487072) |
| Ortholog in Animals | Alpaca_ SLC11A2 ( ortholog_one2one ) Dog_ SLC11A2 ( ortholog_one2one ) GuineaPig_ SLC11A2 ( ortholog_one2one ) Macaque_ SLC11A2 ( ortholog_one2one ) Mouse_ Slc11a2 ( ortholog_one2one ) Pig_ SLC11A2 ( ortholog_one2one ) Rat_ Slc11a2 ( ortholog_one2one ) Rabbit_ SLC11A2 ( ortholog_one2one ) |
| Ohnologs | SLC11A1 |
| Paralogs | SLC11A1 |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed. Isoform 1 is highly expressed in brain. Isoform 2 is highly expressed in spleen, thymus and pancreas. Isoform 3 and isoform 4 are abundantly expressed in duodenum and kidney. {ECO:0000269|PubMed:12209011, ECO:0000269|PubMed:9642100}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 5F0L (X-ray 3.20A ) 5F0M (X-ray 3.10A ) 5F0P (X-ray 2.78A ) 7BLO (EM 9.50A ) 7BLQ (EM 9.20A ) |
| DBSNP | rs760028045 rs121918367 rs121918365 rs121918366 rs144863268 |
| Subcellular location [CC] | [Isoform 2]: Cell membrane {ECO:0000269|PubMed:12475959, ECO:0000269|PubMed:25491917}; Multi-pass membrane protein {ECO:0000305}. Early endosome {ECO:0000269|PubMed:12475959}.; Endosome membrane {ECO:0000269|PubMed:12475959, ECO:0000269|PubMed:18776082, ECO:0000269|PubMed:25491917}; Multi-pass membrane protein {ECO:0000269|PubMed:18776082}. Mitochondrion outer membrane {ECO:0000269|PubMed:24448823}; Multi-pass membrane protein. Cell membrane {ECO:0000269|PubMed:12475959, ECO:0000269|PubMed:25326704, ECO:0000269|PubMed:25491917}; Multi-pass membrane protein {ECO:0000305}. Note=Also found in extracellular vesicles different from exosomes. {ECO:0000269|PubMed:27462458}. |
| Mouse PG classification | NA |
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