| Gene Information | |
|---|---|
| Gene Name | RNF125 |
| Organism | Homo sapiens (Human) |
| Gene Length | 232 |
| Protein Names | E3 ubiquitin-protein ligase RNF125 (EC 2.3.2.27) (RING finger protein 125) (T-cell RING activation protein 1) (TRAC-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000101695 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q96EQ8 |
| Gene Card | RNF125 |
| Uniprot ID | Q96EQ8 |
| Pfam | PF05605; PF18574 |
| In ASD | no |
| Allosteric Prediction | yes (0.219737335) |
| Ortholog in Animals | Alpaca_ RNF125 ( ortholog_one2one ) Dog_ RNF125 ( ortholog_one2one ) GuineaPig_ RNF125 ( ortholog_one2one ) Macaque_ RNF125 ( ortholog_one2one ) Mouse_ Rnf125 ( ortholog_one2one ) Pig_ RNF125 ( ortholog_one2one ) Rat_ Rnf125 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RNF138, RNF114, RNF166, RNF180 |
| Tissue | NA |
| Tissue Specificity | Predominantly expressed in lymphoid tissues, including bone marrow, spleen and thymus. Also weakly expressed in other tissues. Predominant in the CD4(+) and CD8(+) T-cells, suggesting that it is preferentially confined to T-cells. {ECO:0000269|PubMed:12974981, ECO:0000269|PubMed:15843525}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 5DKA (X-ray 1.55A ) |
| DBSNP | rs786201014 rs373764886 rs370242930 |
| Subcellular location [CC] | Golgi apparatus membrane {ECO:0000269|PubMed:17990982}; Lipid-anchor {ECO:0000269|PubMed:17990982}. Note=Shows a reticular staining pattern within the cell and is probably expressed at other intracellular membranes in addition to the Golgi membrane. Not detected at the plasma membrane. {ECO:0000269|PubMed:17990982}. |
| Mouse PG classification | NA |
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