| Gene Information | |
|---|---|
| Gene Name | KIAA1835 |
| Organism | Homo sapiens (Human) |
| Gene Length | 587 |
| Protein Names | Ran GTPase-activating protein 1 (RanGAP1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P46060 |
| Gene Card | RANGAP1 |
| Uniprot ID | P46060 |
| Pfam | PF13516; PF07834 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in brain, thymus and testis. {ECO:0000269|PubMed:8973340}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.109366(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1Z5S (X-ray 3.01A ) 2GRN (X-ray 1.80A ) 2GRO (X-ray 1.70A ) 2GRP (X-ray 2.05A ) 2GRQ (X-ray 1.70A ) 2GRR (X-ray 1.30A ) 2IO2 (X-ray 2.90A ) 2IO3 (X-ray 3.20A ) 2IY0 (X-ray 2.77A ) 3UIN (X-ray 2.60A ) 3UIO (X-ray 2.60A ) 3UIP (X-ray 2.29A ) 5D2M (X-ray 2.40A ) |
| DBSNP | rs2229752 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:15037602, ECO:0000305|PubMed:8146159}. Nucleus, nucleoplasm {ECO:0000269|PubMed:8146159}. Nucleus envelope {ECO:0000269|PubMed:11854305, ECO:0000269|PubMed:15037602}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:11854305}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:11854305, ECO:0000269|PubMed:15037602}. Note=Cytoplasmic during interphase. Detected at the nuclear envelope during interphase (PubMed:11854305, PubMed:15037602). Targeted to the nuclear pores after sumoylation (PubMed:11854305). During mitosis, associates with mitotic spindles, but is essentially not detected at the spindle poles (PubMed:11854305, PubMed:15037602). Association with kinetochores appears soon after nuclear envelope breakdown and persists until late anaphase (PubMed:11854305). Mitotic location also requires sumoylation (PubMed:11854305). {ECO:0000269|PubMed:11854305, ECO:0000269|PubMed:15037602}. |
| Mouse PG classification | NA |
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