| Gene Information | |
|---|---|
| Gene Name | DEFA5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 94 |
| Protein Names | Defensin alpha 5 (Defensin-5) (HD5(20-94)) [Cleaved into: HD5(23-94); HD5(29-94); HD5(56-94); HD5(63-94)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 93 ( ENSG00000164816 ) 3 ( ENSG00000285251 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q01523 |
| Gene Card | DEFA5 |
| Uniprot ID | Q01523 |
| Pfam | PF00323; PF00879 |
| In ASD | no |
| Allosteric Prediction | no (-0.999570004) |
| Ortholog in Animals | Alpaca_ DEFA5 ( ortholog_one2one ) Mouse_ Defa30 ( ortholog_many2many ) Mouse_ Defa25 ( ortholog_many2many ) Mouse_ Defa31 ( ortholog_many2many ) Mouse_ Defa24 ( ortholog_many2many ) Mouse_ Defa38 ( ortholog_many2many ) Mouse_ Defa20 ( ortholog_many2many ) Mouse_ Defa35 ( ortholog_many2many ) Mouse_ Defa32 ( ortholog_many2many ) Mouse_ AY761185 ( ortholog_many2many ) Mouse_ Defa23 ( ortholog_many2many ) Mouse_ Defa36 ( ortholog_many2many ) Mouse_ Defa33 ( ortholog_many2many ) Mouse_ Defa17 ( ortholog_many2many ) Mouse_ Defa29 ( ortholog_many2many ) Mouse_ Defa39 ( ortholog_many2many ) Mouse_ Defa40 ( ortholog_many2many ) Mouse_ Defa2 ( ortholog_many2many ) Mouse_ Defa22 ( ortholog_many2many ) Mouse_ Defa43 ( ortholog_many2many ) Mouse_ Defa27 ( ortholog_many2many ) Mouse_ Defa26 ( ortholog_many2many ) Mouse_ Defa21 ( ortholog_many2many ) Mouse_ Defa34 ( ortholog_many2many ) Mouse_ Defa42 ( ortholog_many2many ) Mouse_ Defa3 ( ortholog_many2many ) Mouse_ Defa28 ( ortholog_many2many ) Mouse_ Defa41 ( ortholog_many2many ) Mouse_ Defa5 ( ortholog_many2many ) Mouse_ Defa37 ( ortholog_many2many ) Rat_ Defa5 ( ortholog_many2many ) Rat_ Defa24 ( ortholog_many2many ) Rat_ RatNP-3b ( ortholog_many2many ) Rat_ Defa9 ( ortholog_many2many ) Rat_ Defa6 ( ortholog_many2many ) Rat_ Defal1 ( ortholog_many2many ) Rat_ Defa7 ( ortholog_many2many ) Rat_ Defa11 ( ortholog_many2many ) Rat_ Np4 ( ortholog_many2many ) Rat_ Defa10 ( ortholog_many2many ) Rat_ Defa8 ( ortholog_many2many ) |
| Ohnologs | NA |
| Paralogs | DEFA6, DEFA4, DEFA1, DEFA3, DEFA1B |
| Tissue | duodenum, small.intestine, colon, small.intestine.Peyers.patch |
| Tissue Specificity | Expressed in the gastrointestinal, reproductive, and urinary tracts (at protein level) (PubMed:1429669, PubMed:12021776, PubMed:9588893, PubMed:22359618). Expressed in Paneth cells of the small intestine (at protein level) (PubMed:1429669, PubMed:12021776). Expressed throughout the urothelium of the lower urinary tract and in the collecting tubules of the kidney (at protein level) (PubMed:22359618). Expressed in stratified squamous epithelial cells of the female genital tract epithelia, such as in vagina, ectocervix, endocervix, endometrium, and fallopian tube (at protein level) (PubMed:9588893). Endometrial expression correlates with stages of the menstrual cycle: Expression is low during the early proliferative phase, increased during the mid- to late proliferative phase, peaks during the early secretory phase of the cycle, and decreases during the mid- to late secretory phase (PubMed:9588893). {ECO:0000269|PubMed:12021776, ECO:0000269|PubMed:1429669, ECO:0000269|PubMed:22359618, ECO:0000269|PubMed:9588893}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1ZMP (X-ray 1.65A ) 2LXZ (NMR - ) 2MIT (NMR - ) 3I5W (X-ray 1.63A ) 4E82 (X-ray 1.70A ) 4E83 (X-ray 1.90A ) 4E86 (X-ray 2.75A ) 4RBW (X-ray 1.50A ) 4RBX (X-ray 1.10A ) 5CUI (X-ray 2.40A ) 5CUJ (X-ray 2.08A ) 5CUM (X-ray 1.75A ) |
| DBSNP | rs7839771 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:12021776, ECO:0000269|PubMed:9588893}. Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:12021776, ECO:0000269|PubMed:9588893}. Note=Stored as propeptide HD5(20-94) in secretory granules of small intestinal Paneth cells and found in the ileum lumen as processed mature peptides, predominantly in the HD5(63-94) form (PubMed:12021776). Peptides HD5(20-94), HD5(23-94) and HD5(29-94) are found within tissues, HD5(20-94) being the predominant intracellular form. Peptides HD5(56-94) and HD5(63-94) are found in the extracellular milieu, HD5(63-94) being the most abundant form (PubMed:12021776). Secreted into the female genital tract lumen (PubMed:9588893). {ECO:0000269|PubMed:12021776, ECO:0000269|PubMed:9588893}. |
| Mouse PG classification | NA |
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