| Gene Information | |
|---|---|
| Gene Name | SIPA1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1042 |
| Protein Names | Signal-induced proliferation-associated protein 1 (Sipa-1) (GTPase-activating protein Spa-1) (p130 SPA-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000213445 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q96FS4 |
| Gene Card | SIPA1 |
| Uniprot ID | Q96FS4 |
| Pfam | PF00595; PF02145 |
| In ASD | no |
| Allosteric Prediction | no (-0.36601649) |
| Ortholog in Animals | Alpaca_ SIPA1 ( ortholog_one2one ) Dog_ SIPA1 ( ortholog_one2one ) GuineaPig_ SIPA1 ( ortholog_one2one ) Macaque_ SIPA1 ( ortholog_one2one ) Mouse_ Sipa1 ( ortholog_one2one ) Pig_ SIPA1 ( ortholog_one2one ) Rat_ Sipa1 ( ortholog_one2one ) |
| Ohnologs | SIPA1L3, SIPA1L1, SIPA1L2 |
| Paralogs | SIPA1L2, SIPA1L1, SIPA1L3, RAP1GAP2, RAP1GAP, GARNL3 |
| Tissue | NA |
| Tissue Specificity | Expressed in fetal as well as in adult tissues. Expressed abundantly in the lymphoid tissues such as thymus, spleen and peripheral blood lymphocytes and also shows a significant expression in the spinal cord. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs35045265 rs3741379 rs34912782 rs3741378 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:9346962}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:9346962}. Endomembrane system; Peripheral membrane protein {ECO:0000269|PubMed:9346962}. Note=Mostly localized in the perinuclear membraneous region. {ECO:0000269|PubMed:9346962}. |
| Mouse PG classification | NA |
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