| Gene Information | |
|---|---|
| Gene Name | MAP3K4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1608 |
| Protein Names | Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAP three kinase 1) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) |
| Target Name | mitogen-activated protein kinase kinase kinase 4 |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000085511 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9Y6R4 |
| Gene Card | MAP3K4 |
| Uniprot ID | Q9Y6R4 |
| Pfam | PF19431; PF00069 |
| In ASD | no |
| Allosteric Prediction | yes (0.429684526) |
| Ortholog in Animals | Alpaca_ MAP3K4 ( ortholog_one2one ) Dog_ MAP3K4 ( ortholog_one2one ) GuineaPig_ MAP3K4 ( ortholog_one2one ) Macaque_ MAP3K4 ( ortholog_one2one ) Mouse_ Map3k4 ( ortholog_one2one ) Pig_ MAP3K4 ( ortholog_one2one ) Rat_ Map3k4 ( ortholog_one2one ) Rabbit_ MAP3K4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NEK1, MAP2K2, MAP2K1, MAP3K2, MAP2K4, MAP3K3, MAP2K7, MAP2K5 |
| Tissue | NA |
| Tissue Specificity | Expressed at high levels in heart, placenta, skeletal muscle and pancreas, and at lower levels in other tissues. {ECO:0000269|PubMed:9305639}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.009091(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs4559074 rs35842248 rs35730939 rs55765351 rs34018542 rs35533223 rs41267837 |
| Subcellular location [CC] | Cytoplasm, perinuclear region {ECO:0000250}. Note=Localized in perinuclear vesicular-like structures, probably Golgi-associated vesicles. {ECO:0000250}. |
| Mouse PG classification | NA |
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