| Gene Information | |
|---|---|
| Gene Name | NFATC1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 943 |
| Protein Names | Nuclear factor of activated T-cells, cytoplasmic 1 (NF-ATc1) (NFATc1) (NFAT transcription complex cytosolic component) (NF-ATc) (NFATc) |
| Target Name | nuclear factor of activated t-cells, cytoplasmic 1 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000131196 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O95644 |
| Gene Card | NFATC1 |
| Uniprot ID | O95644 |
| Pfam | PF16179; PF00554 |
| In ASD | yes |
| Allosteric Prediction | yes (1.000152593) |
| Ortholog in Animals | Alpaca_ NFATC1 ( ortholog_one2one ) Dog_ NFATC1 ( ortholog_one2one ) GuineaPig_ NFATC1 ( ortholog_one2one ) Macaque_ NFATC1 ( ortholog_one2one ) Mouse_ Nfatc1 ( ortholog_one2one ) Pig_ NFATC1 ( ortholog_one2one ) Rat_ Nfatc1 ( ortholog_one2one ) |
| Ohnologs | NFATC2, NFATC3, NFATC4 |
| Paralogs | NFATC3, NFATC4, NFAT5, NFATC2 |
| Tissue | NA |
| Tissue Specificity | Expressed in thymus, peripheral leukocytes as T-cells and spleen. Isoforms A are preferentially expressed in effector T-cells (thymus and peripheral leukocytes) whereas isoforms B and isoforms C are preferentially expressed in naive T-cells (spleen). Isoforms B are expressed in naive T-cells after first antigen exposure and isoforms A are expressed in effector T-cells after second antigen exposure. Isoforms IA are widely expressed but not detected in liver nor pancreas, neural expression is strongest in corpus callosum. Isoforms IB are expressed mostly in muscle, cerebellum, placenta and thymus, neural expression in fetal and adult brain, strongest in corpus callosum. {ECO:0000269|PubMed:18675896}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.027573(Mouse);0.002240(Rat);0.057143(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1A66 (NMR - ) 1NFA (NMR - ) 5SVE (X-ray 2.60A ) |
| DBSNP | rs1051978 rs779866756 rs754093 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:16511445}. Nucleus {ECO:0000269|PubMed:16511445}. Note=Cytoplasmic for the phosphorylated form and nuclear after activation that is controlled by calcineurin-mediated dephosphorylation. Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals. The subcellular localization of NFATC plays a key role in the regulation of gene transcription (PubMed:16511445). Nuclear translocation of NFATC1 is enhanced in the presence of TNFSF11. Nuclear translocation is decreased in the presence of FBN1 which can bind and sequester TNFSF11 (By similarity). {ECO:0000250|UniProtKB:O88942, ECO:0000269|PubMed:16511445}. |
| Mouse PG classification | NA |
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