| Gene Information | |
|---|---|
| Gene Name | CYP26A1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 497 |
| Protein Names | Cytochrome P450 26A1 (EC 1.14.13.-) (Cytochrome P450 retinoic acid-inactivating 1) (Cytochrome P450RAI) (hP450RAI) (Retinoic acid 4-hydroxylase) (Retinoic acid-metabolizing cytochrome) |
| Target Name | cytochrome p450 26 |
| Target Type | Clinical trial target |
| Gene Age | 680 ( ENSG00000095596 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | O43174 |
| Gene Card | CYP26A1 |
| Uniprot ID | O43174 |
| Pfam | PF00067 |
| In ASD | no |
| Allosteric Prediction | no (-0.25113633) |
| Ortholog in Animals | Alpaca_ CYP26A1 ( ortholog_one2one ) Dog_ CYP26A1 ( ortholog_one2one ) GuineaPig_ CYP26A1 ( ortholog_one2one ) Macaque_ CYP26A1 ( ortholog_one2one ) Mouse_ Cyp26a1 ( ortholog_one2one ) Pig_ CYP26A1 ( ortholog_one2one ) Rat_ Cyp26a1 ( ortholog_one2one ) Rabbit_ CYP26A1 ( ortholog_one2one ) |
| Ohnologs | CYP26B1 |
| Paralogs | CYP26C1, CYP26B1 |
| Tissue | liver |
| Tissue Specificity | Expressed in most fetal and adult tissues with highest levels in adult liver, heart, pituitary gland, adrenal gland, placenta and regions of the brain (PubMed:9826557). Expressed at high levels in lung, pancreas, skin and uterus (at protein level) (PubMed:22020119). Lower expression level is detected in spleen, kidney, intestine and adipose tissue (at protein level) (PubMed:22020119). {ECO:0000269|PubMed:22020119, ECO:0000269|PubMed:9826557}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000305|PubMed:9716180}; Peripheral membrane protein. Microsome membrane {ECO:0000269|PubMed:9716180}; Peripheral membrane protein. |
| Mouse PG classification | NA |
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