| Gene Information | |
|---|---|
| Gene Name | KIAA1695 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1422 |
| Protein Names | FH1/FH2 domain-containing protein 3 (Formactin-2) (Formin homolog overexpressed in spleen 2) (hFHOS2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q2V2M9 |
| Gene Card | FHOD3 |
| Uniprot ID | Q2V2M9 |
| Pfam | PF02181; PF18382 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in the heart, kidney and brain. May be down-regulated in various types of heart diseases, including idiopathic dilated, ventricular dilated, familial dilated and perinatal dilated cardiomyopathies, as well as ischemic heart disease (at protein level). {ECO:0000269|PubMed:15966898, ECO:0000269|PubMed:21149568}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs752857554 rs760471234 rs758818742 rs370344363 rs774149210 rs9964535 rs368544178 rs1451852171 rs757717851 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:21149568}. Note=Main part of the protein localizes to actin fibers and the remaining part displays filamentous staining. {ECO:0000250}.; [Isoform 4]: Cytoplasm, myofibril, sarcomere, Z line. Note=Threonine phosphorylation in isoform 4-specific sequence TDTDEEEEVE is required for targeting to myofibrils in cardiomyocytes. |
| Mouse PG classification | NA |
| click here to return to the previous page | |