| Gene Information | |
|---|---|
| Gene Name | KRT17 |
| Organism | Homo sapiens (Human) |
| Gene Length | 432 |
| Protein Names | Keratin, type I cytoskeletal 17 (39.1) (Cytokeratin-17) (CK-17) (Keratin-17) (K17) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000128422 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q04695 |
| Gene Card | KRT17 |
| Uniprot ID | Q04695 |
| Pfam | PF00038 |
| In ASD | no |
| Allosteric Prediction | no (-0.848738013) |
| Ortholog in Animals | Alpaca_ KRT17 ( ortholog_one2one ) Mouse_ Krt17 ( ortholog_one2one ) Pig_ KRT17 ( ortholog_one2one ) Rat_ Krt17 ( ortholog_one2one ) Rabbit_ KRT17 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | VIM, KRT12, KRT74, INA, NEFM, KRT39, SYNM, KRT13, KRT80, KRT33B, KRT31, KRT77, KRT26, KRT32, KRT73, KRT28, KRT37, KRT38, KRT6B, KRT6A, KRT6C, KRT72, KRT20, KRT5, KRT222, LMNB1, PRPH, KRT23, KRT4, KRT36, KRT7, KRT34, KRT75, KRT25, KRT76, KRT35, KRT78, KRT24, KRT40, KRT86, KRT83, KRT81, NES, DES, KRT2, KRT9, KRT27, KRT3, KRT84, LMNB2, KRT33A, KRT82, BFSP2, KRT14, KRT16, KRT85, LMNA, KRT8, GFAP, KRT79, KRT71, KRT1, KRT19, LMNTD1, NEFL, KRT15, KRT18, KRT10 |
| Tissue | urinary.bladder, lower.leg.skin, suprapubic.skin |
| Tissue Specificity | Expressed in the outer root sheath and medulla region of hair follicle specifically from eyebrow and beard, digital pulp, nail matrix and nail bed epithelium, mucosal stratified squamous epithelia and in basal cells of oral epithelium, palmoplantar epidermis and sweat and mammary glands. Also expressed in myoepithelium of prostate, basal layer of urinary bladder, cambial cells of sebaceous gland and in exocervix (at protein level). {ECO:0000269|PubMed:10651700, ECO:0000269|PubMed:10844551, ECO:0000269|PubMed:1281771, ECO:0000269|PubMed:2481679}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs28928898 rs28928898 rs28928896 rs28928896 rs59151893 rs58730926 rs28928897 rs28928897 rs28928899 rs28928899 rs28933088 rs28933089 rs59977263 rs267607412 rs56690581 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:Q9QWL7}. |
| Mouse PG classification | HPG |
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