| Gene Information | |
|---|---|
| Gene Name | DEPDC5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1603 |
| Protein Names | GATOR complex protein DEPDC5 (DEP domain-containing protein 5) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000100150 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O75140 |
| Gene Card | DEPDC5 |
| Uniprot ID | O75140 |
| Pfam | PF00610; PF19418; PF12257 |
| In ASD | no |
| Allosteric Prediction | no (-0.644037639) |
| Ortholog in Animals | Alpaca_ DEPDC5 ( ortholog_one2many ) Dog_ DEPDC5 ( ortholog_one2one ) GuineaPig_ DEPDC5 ( ortholog_one2one ) Macaque_ DEPDC5 ( ortholog_one2one ) Mouse_ Depdc5 ( ortholog_one2one ) Pig_ DEPDC5 ( ortholog_one2one ) Rat_ Depdc5 ( ortholog_one2one ) Rabbit_ DEPDC5 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in developing and adult brain. {ECO:0000269|PubMed:23542701}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6CES (EM 4.00A ) 6CET (EM 4.40A ) 7T3A (EM 4.00A ) 7T3B (EM 3.90A ) 7T3C (EM 4.00A ) |
| DBSNP | rs768456731 rs886039276 rs187334123 rs202226316 rs886039278 rs8138516 rs886039279 rs16989528 rs16989535 rs564667614 rs757609394 rs754608531 rs142540948 rs79027628 rs578244490 rs886039280 rs886039281 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000250|UniProtKB:P61460}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P61460}. Lysosome membrane {ECO:0000269|PubMed:28199306}. Note=Localization to lysosomes is amino acid-independent. {ECO:0000269|PubMed:28199306}. |
| Mouse PG classification | LPG |
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