| Gene Information | |
|---|---|
| Gene Name | IFIH1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1025 |
| Protein Names | Interferon-induced helicase C domain-containing protein 1 (EC 3.6.4.13) (Clinically amyopathic dermatomyositis autoantigen 140 kDa) (CADM-140 autoantigen) (Helicase with 2 CARD domains) (Helicard) (Interferon-induced with helicase C domain protein 1) (Melanoma differentiation-associated protein 5) (MDA-5) (Murabutide down-regulated protein) (RIG-I-like receptor 2) (RLR-2) (RNA helicase-DEAD box protein 116) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000115267 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9BYX4 |
| Gene Card | IFIH1 |
| Uniprot ID | Q9BYX4 |
| Pfam | PF16739; PF00271; PF04851; PF18119; PF11648 |
| In ASD | no |
| Allosteric Prediction | yes (0.166049854) |
| Ortholog in Animals | Alpaca_ IFIH1 ( ortholog_one2one ) Dog_ IFIH1 ( ortholog_one2one ) GuineaPig_ IFIH1 ( ortholog_one2one ) Mouse_ Ifih1 ( ortholog_one2one ) Pig_ IFIH1 ( ortholog_one2one ) Rat_ Ifih1 ( ortholog_one2one ) Rabbit_ IFIH1 ( ortholog_one2one ) |
| Ohnologs | DHX58 |
| Paralogs | DHX58, DDX58 |
| Tissue | NA |
| Tissue Specificity | Widely expressed, at a low level. Expression is detected at slightly highest levels in placenta, pancreas and spleen and at barely levels in detectable brain, testis and lung. {ECO:0000269|PubMed:11805321, ECO:0000269|PubMed:12015121, ECO:0000269|PubMed:14645903}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2RQB (NMR - ) 3B6E (X-ray 1.60A ) 3GA3 (X-ray 1.45A ) 4GL2 (X-ray 3.56A ) 7DNI (EM 3.20A ) 7DNJ (EM 3.30A ) 7JL0 (EM 4.30A ) 7JL2 (EM 4.30A ) |
| DBSNP | rs587777447 rs587777576 rs587777449 rs587777575 rs10930046 rs672601336 rs587777445 rs587777448 rs587777446 rs376048533 rs3747517 rs1990760 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:11805321, ECO:0000269|PubMed:14645903, ECO:0000269|PubMed:32169843, ECO:0000269|PubMed:33727702}. Nucleus {ECO:0000305}. Mitochondrion {ECO:0000269|PubMed:33727702}. Note=Upon viral RNA stimulation and ISGylation, translocates from cytosol to mitochondrion. May be found in the nucleus, during apoptosis. |
| Mouse PG classification | LPG |
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