| Gene Information | |
|---|---|
| Gene Name | KIAA1428 |
| Organism | Homo sapiens (Human) |
| Gene Length | 709 |
| Protein Names | DCC-interacting protein 13-alpha (Dip13-alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9UKG1 |
| Gene Card | APPL1 |
| Uniprot ID | Q9UKG1 |
| Pfam | PF00169; PF00640 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | High levels in heart, ovary, pancreas and skeletal muscle. {ECO:0000269|PubMed:10490823}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001445(Rat);0.014815(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2EJ8 (X-ray 1.84A ) 2ELA (X-ray 2.00A ) 2ELB (X-ray 2.60A ) 2Q12 (X-ray 1.79A ) 2Q13 (X-ray 2.05A ) 2Z0N (X-ray 1.95A ) 2Z0O (X-ray 2.58A ) 5C5B (X-ray 2.90A ) |
| DBSNP | rs796065047 rs4381906 rs11544593 |
| Subcellular location [CC] | Early endosome membrane {ECO:0000269|PubMed:15016378, ECO:0000269|PubMed:20133602, ECO:0000269|PubMed:21645192}; Peripheral membrane protein {ECO:0000269|PubMed:15016378}. Nucleus {ECO:0000269|PubMed:15016378, ECO:0000269|PubMed:19433865, ECO:0000269|PubMed:26583432}. Cytoplasm {ECO:0000269|PubMed:19433865, ECO:0000269|PubMed:19661063}. Endosome {ECO:0000269|PubMed:26583432}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q8K3H0}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:Q8K3H0}. Note=Early endosomal membrane-bound and nuclear. Translocated into the nucleus upon release from endosomal membranes following internalization of EGF. {ECO:0000269|PubMed:15016378}. |
| Mouse PG classification | NA |
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