Gene Information
Gene NameNSD3
OrganismHomo sapiens (Human)
Gene Length1437
Protein NamesHistone-lysine N-methyltransferase NSD3 (EC 2.1.1.370) (EC 2.1.1.371) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1)
Target NameNA
Target TypeNA
Gene Age1488 ( ENSG00000147548 )
Evolutionary StageEukaryota
AlphaFoldDBQ9BZ95
Gene CardNSD3
Uniprot IDQ9BZ95
PfamPF17907; PF17982; PF00855; PF00856
In ASDno
Allosteric Predictionno (-0.455161616)
Ortholog in AnimalsAlpaca_ NSD3 ( ortholog_one2one )
Dog_ NSD3 ( ortholog_one2one )
GuineaPig_ NSD3 ( ortholog_one2one )
Macaque_ NSD3 ( ortholog_one2one )
Mouse_ Nsd3 ( ortholog_one2one )
Pig_ NSD3 ( ortholog_one2one )
Rat_ Nsd3 ( ortholog_one2one )
Rabbit_ NSD3 ( ortholog_one2one )
OhnologsNSD2, NSD1
ParalogsKMT2B, ASH1L, EHMT2, SUV39H1, EZH1, KMT2A, SETBP1, SETD2, SETD1B, SETD1A, SUV39H2, EHMT1, KMT2D, NSD2, SETDB2, EZH2, KMT2C, NSD1, SETDB1
TissueNA
Tissue SpecificityHighly expressed in brain, heart and skeletal muscle. Expressed at lower level in liver and lung. {ECO:0000269|PubMed:11374904}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2DAQ  (NMR  2NCZ  (NMR  2ND1  (NMR  4GND  (X-ray  2.27A  4GNE  (X-ray  1.47A  4GNF  (X-ray  1.55A  4GNG  (X-ray  1.73A  4RXJ  (X-ray  2.10A  5UPD  (X-ray  1.80A  6CEN  (X-ray  1.61A  6G24  (X-ray  2.10A  6G25  (X-ray  1.43A  6G27  (X-ray  1.65A  6G29  (X-ray  1.70A  6G2B  (X-ray  1.61A  6G2C  (X-ray  1.76A  6G2E  (X-ray  1.85A  6G2F  (X-ray  1.74A  6G2O  (X-ray  1.81A  6G3P  (X-ray  2.80A  6G3T  (X-ray  2.53A  7CRP  (EM  3.20A  7CRQ  (EM  3.15A  7CRR  (EM  3.48A  7JYN  (NMR 
DBSNP rs13034  rs2234552 
Subcellular location [CC]Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
Mouse PG classificationNA
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