| Gene Information | |
|---|---|
| Gene Name | KIAA1379 |
| Organism | Homo sapiens (Human) |
| Gene Length | 444 |
| Protein Names | Protein kinase C and casein kinase substrate in neurons protein 1 (Syndapin-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9BY11 |
| Gene Card | PACSIN1 |
| Uniprot ID | Q9BY11 |
| Pfam | PF00611; PF14604 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in brain and, at much lower levels, in heart and pancreas. {ECO:0000269|PubMed:11179684}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.105(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3HAH (X-ray 2.77A ) 3HAI (X-ray 2.88A ) 3Q84 (X-ray 2.80A ) 3QNI (X-ray 2.80A ) |
| DBSNP | rs41312309 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. Cell projection {ECO:0000250}. Synapse, synaptosome {ECO:0000250}. Cell projection, ruffle membrane {ECO:0000250}. Membrane; Peripheral membrane protein. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Synapse {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Colocalizes with MAPT in axons. In primary neuronal cultures, present at a high level in presynaptic nerve terminals and in the cell body. Colocalizes with DNM1 at vesicular structures in the cell body and neurites (By similarity). Associates with membranes via its F-BAR domain. {ECO:0000250}. |
| Mouse PG classification | NA |
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