Gene Information
Gene NameDEFA6
OrganismHomo sapiens (Human)
Gene Length100
Protein NamesDefensin-6 (Defensin, alpha 6)
Target NameNA
Target TypeNA
Gene Age93 ( ENSG00000164822 )
3 ( ENSG00000285136 )
Evolutionary StageMammalia
AlphaFoldDBQ01524
Gene CardDEFA6
Uniprot IDQ01524
PfamPF00323; PF00879
In ASDno
Allosteric Predictionno (-1.033934183)
Ortholog in AnimalsAlpaca_ DEFA6 ( ortholog_one2one )
Macaque_ DEFA6 ( ortholog_one2one )
Mouse_ Defa30 ( ortholog_many2many )
Mouse_ Defa25 ( ortholog_many2many )
Mouse_ Defa31 ( ortholog_many2many )
Mouse_ Defa24 ( ortholog_many2many )
Mouse_ Defa38 ( ortholog_many2many )
Mouse_ Defa20 ( ortholog_many2many )
Mouse_ Defa35 ( ortholog_many2many )
Mouse_ Defa32 ( ortholog_many2many )
Mouse_ AY761185 ( ortholog_many2many )
Mouse_ Defa23 ( ortholog_many2many )
Mouse_ Defa36 ( ortholog_many2many )
Mouse_ Defa33 ( ortholog_many2many )
Mouse_ Defa17 ( ortholog_many2many )
Mouse_ Defa29 ( ortholog_many2many )
Mouse_ Defa39 ( ortholog_many2many )
Mouse_ Defa40 ( ortholog_many2many )
Mouse_ Defa2 ( ortholog_many2many )
Mouse_ Defa22 ( ortholog_many2many )
Mouse_ Defa43 ( ortholog_many2many )
Mouse_ Defa27 ( ortholog_many2many )
Mouse_ Defa26 ( ortholog_many2many )
Mouse_ Defa21 ( ortholog_many2many )
Mouse_ Defa34 ( ortholog_many2many )
Mouse_ Defa42 ( ortholog_many2many )
Mouse_ Defa3 ( ortholog_many2many )
Mouse_ Defa28 ( ortholog_many2many )
Mouse_ Defa41 ( ortholog_many2many )
Mouse_ Defa5 ( ortholog_many2many )
Mouse_ Defa37 ( ortholog_many2many )
Rat_ Defa5 ( ortholog_many2many )
Rat_ Defa24 ( ortholog_many2many )
Rat_ RatNP-3b ( ortholog_many2many )
Rat_ Defa9 ( ortholog_many2many )
Rat_ Defa6 ( ortholog_many2many )
Rat_ Defal1 ( ortholog_many2many )
Rat_ Defa7 ( ortholog_many2many )
Rat_ Defa11 ( ortholog_many2many )
Rat_ Np4 ( ortholog_many2many )
Rat_ Defa10 ( ortholog_many2many )
Rat_ Defa8 ( ortholog_many2many )
OhnologsNA
ParalogsDEFA5, DEFA4, DEFA1, DEFA3, DEFA1B
Tissueduodenum, small.intestine, colon, small.intestine.Peyers.patch
Tissue SpecificityExpressed in Paneth cells of the small intestine (at protein level). {ECO:0000269|PubMed:27076903, ECO:0000269|PubMed:8417977, ECO:0000269|PubMed:8626737}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1ZMQ  (X-ray  2.10A  3QTE  (X-ray  1.95A 
DBSNP NA 
Subcellular location [CC]Secreted {ECO:0000269|PubMed:27076903}. Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:27076903}. Note=Stored as propeptide in secretory granules of small intestinal Paneth cells and found in the ileum lumen as mature peptide. {ECO:0000269|PubMed:27076903}.
Mouse PG classificationNA
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