Gene Information
Gene NameS100A16
OrganismHomo sapiens (Human)
Gene Length103
Protein NamesProtein S100-A16 (Aging-associated gene 13 protein) (Protein S100-F) (S100 calcium-binding protein A16)
Target Nameprotein s100-a16
Target TypeNA
Gene Age332 ( ENSG00000188643 )
Evolutionary StageMammalia
AlphaFoldDBQ96FQ6
Gene CardS100A16
Uniprot IDQ96FQ6
PfamPF01023
In ASDno
Allosteric Predictionno (-1.053587745)
Ortholog in AnimalsAlpaca_ S100A16 ( ortholog_one2one )
Dog_ S100A16 ( ortholog_one2one )
GuineaPig_ S100A16 ( ortholog_one2one )
Macaque_ S100A16 ( ortholog_one2one )
Mouse_ S100a16 ( ortholog_one2one )
Rat_ S100a16 ( ortholog_one2one )
OhnologsNA
ParalogsS100A3, S100A10, S100A4, SNTN, S100A8, S100A13, S100A11, S100A5, S100B, S100A14, S100Z, S100A1, S100A12, S100P, S100G, S100A2, S100A7, S100A7A, CRNN, S100A9, S100A6
TissueNA
Tissue SpecificityUbiquitous (PubMed:14684152). Highly expressed in esophagus, adipose tissues and colon. Expressed at lower level in lung, brain, pancreas and skeletal muscle. Expression is up-regulated in tumors of bladder, lung, thyroid gland, pancreas and ovary (PubMed:14684152). Expressed in astrocytes (PubMed:17030513). {ECO:0000269|PubMed:14684152, ECO:0000269|PubMed:17030513}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2L50  (NMR  -  )  2L51  (NMR  -  )  3NXA  (X-ray  2.10A  ) 
DBSNP NA 
Subcellular location [CC]Nucleus, nucleolus {ECO:0000269|PubMed:17030513}. Cytoplasm {ECO:0000269|PubMed:17030513}. Note=Primarily nucleolar. A high intracellular calcium level induces nucleolar exit and nucleocytoplasmic transport, whereas a low intracellular calcium level leads to nuclear translocation and accumulation within specific region of nucleoli (PubMed:17030513).
Mouse PG classificationNA
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