| Gene Information | |
|---|---|
| Gene Name | SLC2A9 |
| Organism | Homo sapiens (Human) |
| Gene Length | 540 |
| Protein Names | Solute carrier family 2, facilitated glucose transporter member 9 (Glucose transporter type 9) (GLUT-9) (Urate transporter) |
| Target Name | glucose transporter type 9 |
| Target Type | Discontinued target |
| Gene Age | >4290 ( ENSG00000109667 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9NRM0 |
| Gene Card | SLC2A9 |
| Uniprot ID | Q9NRM0 |
| Pfam | PF00083 |
| In ASD | no |
| Allosteric Prediction | no (-0.343708813) |
| Ortholog in Animals | Alpaca_ SLC2A9 ( ortholog_one2one ) Dog_ SLC2A9 ( ortholog_one2one ) GuineaPig_ SLC2A9 ( ortholog_one2one ) Macaque_ SLC2A9 ( ortholog_one2one ) Mouse_ Slc2a9 ( ortholog_one2one ) Pig_ SLC2A9 ( ortholog_one2one ) Rat_ Slc2a9 ( ortholog_one2one ) Rabbit_ SLC2A9 ( ortholog_one2one ) |
| Ohnologs | SLC2A5, SLC2A7 |
| Paralogs | SLC2A8, SLC2A7, SLC2A6, SLC2A5, SLC2A11, SLC2A2, SLC2A1, SLC2A4, SLC2A3, SLC2A14, SLC2A13, SLC2A12, SLC2A10 |
| Tissue | kidney |
| Tissue Specificity | [Isoform 1]: Most strongly expressed in basolateral membranes of proximal renal tubular cells, liver and placenta. Also detected in lung, blood leukocytes, heart skeletal muscle and chondrocytes from articular cartilage. Detected in kidney membrane (at protein level). {ECO:0000269|PubMed:11991658, ECO:0000269|PubMed:24409316}.; [Isoform 2]: Only detected in the apical membranes of polarized renal tubular cells and placenta. Detected in kidney membrane (at protein level). {ECO:0000269|PubMed:24409316}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs2276961 rs863225072 rs181509591 rs144196049 rs776127501 rs376990050 rs121908322 rs561633150 rs112404957 rs73225891 rs16890979 rs3733591 rs145688560 rs2280205 rs121908321 rs6820230 |
| Subcellular location [CC] | [Isoform 1]: Cell membrane {ECO:0000269|PubMed:18701466}; Multi-pass membrane protein. Basolateral cell membrane {ECO:0000269|PubMed:14739288, ECO:0000269|PubMed:24409316}; Multi-pass membrane protein {ECO:0000269|PubMed:14739288}.; [Isoform 2]: Cell membrane {ECO:0000269|PubMed:18701466}. Apical cell membrane {ECO:0000269|PubMed:24409316}; Multi-pass membrane protein. Basolateral cell membrane {ECO:0000269|PubMed:14739288, ECO:0000269|PubMed:24409316}; Multi-pass membrane protein {ECO:0000269|PubMed:14739288}. |
| Mouse PG classification | HPG |
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