| Gene Information | |
|---|---|
| Gene Name | KIAA1228 |
| Organism | Homo sapiens (Human) |
| Gene Length | 921 |
| Protein Names | Extended synaptotagmin-2 (E-Syt2) (Chr2Syt) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | A0FGR8 |
| Gene Card | ESYT2 |
| Uniprot ID | A0FGR8 |
| Pfam | PF00168; PF17047 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed with high level in cerebellum. {ECO:0000269|PubMed:17360437}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2DMG (NMR - ) 4NPJ (X-ray 2.10A ) 4NPK (X-ray 2.55A ) 4P42 (X-ray 2.44A ) |
| DBSNP | rs13233513 rs2305473 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:17360437, ECO:0000269|PubMed:20833364, ECO:0000269|PubMed:23791178, ECO:0000269|PubMed:29469807}; Peripheral membrane protein {ECO:0000269|PubMed:17360437}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:23791178, ECO:0000269|PubMed:29469807}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to endoplasmic reticulum-plasma membrane contact sites (EPCS) (PubMed:29469807, PubMed:23791178, PubMed:30220461, PubMed:27044890). Recruited to the cell membrane via the third C2 domain (PubMed:17360437). {ECO:0000269|PubMed:17360437, ECO:0000269|PubMed:23791178, ECO:0000269|PubMed:29469807, ECO:0000269|PubMed:30220461}. |
| Mouse PG classification | NA |
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