| Gene Information | |
|---|---|
| Gene Name | KIAA1225 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1412 |
| Protein Names | Erbin (Densin-180-like protein) (Erbb2-interacting protein) (Protein LAP2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q96RT1 |
| Gene Card | ERBIN |
| Uniprot ID | Q96RT1 |
| Pfam | PF13855; PF00595 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in brain, heart, kidney, muscle and stomach, followed by liver, spleen and intestine. {ECO:0000269|PubMed:10878805}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.057143(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1MFG (X-ray 1.25A ) 1MFL (X-ray 1.88A ) 1N7T (NMR - ) 2H3L (X-ray 1.00A ) 2QBW (X-ray 1.80A ) 3CH8 (X-ray 1.90A ) 6Q0M (X-ray 1.20A ) 6Q0N (X-ray 1.18A ) 6Q0U (X-ray 1.89A ) 6UBH (X-ray 1.80A ) 7LUL (X-ray 1.65A ) |
| DBSNP | rs3213837 rs191137999 rs16894812 rs34521887 rs35601230 rs3805466 |
| Subcellular location [CC] | Cell junction, hemidesmosome {ECO:0000269|PubMed:10878805, ECO:0000269|PubMed:11375975}. Nucleus membrane {ECO:0000250}. Basolateral cell membrane {ECO:0000269|PubMed:16203728}. Note=Found in hemidesmosomes, which are cell-substrate adhesion complexes in stratified epithelia. In transfected cells, either diffusely distributed over the cytoplasm or concentrated at the basolateral membrane. Colocalizes with the adrenergic receptors, ADREN1A and ADREN1B, at the nuclear membrane of cardiac myocytes (By similarity). {ECO:0000250}. |
| Mouse PG classification | NA |
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